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儿童紫癜性肾炎的临床和病理研究
引用本文:张宇,卢立肖. 儿童紫癜性肾炎的临床和病理研究[J]. 中国中西医结合肾病杂志, 2008, 9(11): 981-983
作者姓名:张宇  卢立肖
作者单位:1. 浙江省温州市第二人民医院儿科,温州,25000
2. 温州医学院附属育荚儿童医院肾内科,温州,325003
基金项目:浙江省温州市科技局资助项目
摘    要:目的:探讨儿童紫癜性肾炎(HSPN)的临床和肾组织病理改变特点及其关系。方法:回顾性分析1995年12月~2007年12月进行过肾活检的105例HSPN患儿的临床和肾组织病理改变情况。结果:105例HSPN患儿中,单纯血尿组18例(17.14%),血尿及蛋白尿组61例(58.10%),肾病综合征组26例(24.76%);三组间的Scr、BUN、IgA、IgE、CRP和C3水平均无统计学差异(P均〉0.05),血浆白蛋白在各组间存在统计学差异(P均〈0.01)。病理上ISKDC分级结果为:Ⅱa级8例(7.62%),Ⅱb级21例(20.00%),Ⅲa级33例(31.43%),Ⅲb级38例(36.19%),Ⅳ级5例(4.76%);三组间比较有统计学差异(χ^2=44.51,P〈0.01)。肾小管间质病变的组织学分级结果为:(-)级34例(32.38%),(+)级64例(60.95%),(++)级6例(5.71%),(+++)级1例(0.95%),(++++)级0例(0%);三组间比较有统计学差异(χ^2=40.59,P〈0.01)。结论:儿童HSPN临床表现多样,肾病理改变相对较轻,且两者之间存在密切关系。

关 键 词:紫癜性肾炎  儿童  病理  临床

Clinical and Pathological Analysis of Henoch-Schonlein Purpura Nephritis in Children
ZHANG Yu,LU Lixiao. Clinical and Pathological Analysis of Henoch-Schonlein Purpura Nephritis in Children[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2008, 9(11): 981-983
Authors:ZHANG Yu  LU Lixiao
Affiliation:ZHANG Yu,LU Lixiao Department of Pediatrics,the Second People's Hospital of Wenzhou,Wenzhou (325000)
Abstract:Objective:To investigate the clinical and renal pathologic features of Henoch-Schonlein Purpura Nephritis(HSPN) in Children and the relationship between them.Methods:A retrospective review of 105 cases of HSPN who had been performed renal biopsy within 12 years(1995 to 2007) were conducted to analyse their clinical manifestations and renal pathologic features.Results:In 105 children with HSPN,there were 18(17.14%) children with isolated hematuria,61(58.10%) with hematuria and proteinuria,and 26(24.76%) with...
Keywords:Henoch-Schonlein purpura nephritis(HSPN) Children Pathology Clinic  
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