EGFR/PI3K/Akt细胞信号传导通路与肿瘤 |
| |
引用本文: | 孙栋勋[综述],;蔡志毅[审校]. EGFR/PI3K/Akt细胞信号传导通路与肿瘤[J]. 检验医学, 2014, 0(7): 768-773 |
| |
作者姓名: | 孙栋勋[综述], 蔡志毅[审校] |
| |
作者单位: | [1]温州医科大学第一临床医学院,浙江温州325000; [2]台州学院医学院附属市立医院耳鼻咽喉-头颈外科,浙江台州318000 |
| |
基金项目: | 浙江省医药卫生科技项目(2013KYB293) |
| |
摘 要: | 表皮生长因子受体(EGFR)/磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(PKB,也称Akt)信号通路是生物体内一条非常重要的生存信号通路。EGFR通过二聚化后刺激Ras蛋白,导致磷酸化级联反应的发生来激活PI3K/Akt信号通路,从而引起肿瘤的发生发展。本文从EGFR/PI3K/Akt信号传导通路对肿瘤的调节机制等多个方面综述了EGFR/PI3K/Akt信号通路与肿瘤的关系。
|
关 键 词: | 表皮生长因子受体 磷脂酰肌醇3-激酶 蛋白激酶B 肿瘤 |
EGFR /PI3K /Akt signaling pathway with tumor |
| |
Affiliation: | SUN Dongxun, CAI Zhiyi ( 1. The First Clinical Medical Institute, Wenzhou Medical College, Zhejiang Wenzhou 325000, China; 2. Department of Otolaryngology , Municipal Hospital Affiliated to Taizhou University School of Medicine, Zhejiang Taizhou 318000, China) |
| |
Abstract: | Epidermal growth factor receptor( EGFR) /phosphatidylinositol-3-kinase( PI3K) /protein kinase B( PKB,or Akt) signaling pathway is a very important survival signaling pathway. EGFR dimerization pattern can stimulate Ras protein,which leads to a cascade of phosphorylation and activation of PI3 K /Akt signaling pathway,and then leads to the occurence of tumors. This review summarizes the relationship between EGFR /PI3 K /Akt signaling pathway and tumor by analyzing the function of EGFR /PI3 K /Akt signaling pathway. |
| |
Keywords: | Epidermal growth factor receptor Phosphatidylinositol-3-kinase Protein kinase B Tumor |
本文献已被 CNKI 维普 等数据库收录! |
|