2型糖尿病微血管病变患者血清血小板反应蛋白-1水平的变化及临床意义

目的 探讨2型糖尿病T2DM微血管病变与血清血小板反应蛋白-1（TSP-1）的相关性。 方法 将176例受试者研究对象分为糖尿病合并有微血管病变组组（A组，n=58例）、无、未合并微血管病变组（B组，n=64例）和与正常对照组（C组，，n=54例），检测所有研究对象血清TSP-1水平及相关临床指标，并计算胰岛素抵抗指数（HOMA-IR）、胰岛β细胞功能指数（HOMA-β）。 结果 A组及、B组的血清TSP-1水平均显著高于C组（P〈0.05），A组的血清TSP-1水平显著高于B组（P〈0.05）。相关分析示，血清TSP-1水平与FBG、HbA1Cc、hs-C-RP呈正相关（P〈0.01），与HOMA-β指数及FINSns呈负相关（P〈0.01）。多元线性逐步回归结果显示：，HbA1Cc、FPG、HOMA-β及FINSns是血清TSP-1水平的独立影响因素（P〈0.05）。 结论 TSP-1在2型糖尿病T2DM微血管病变患者血清中表达升高，其可能参与糖尿病微血管病变病理生理过程，检测血清TSP-1的水平对预测糖尿病微血管病变有一定的价值。

Research of serum thrombospondin 1 levels in T2DM patients with microangiopathy complications

Objective To explore the relationship of serum thrombospondin -1 （TSP-1） in T2DM patients with microangiopathy complications in T2DM patients . Methods A total of 176 cases were divided into 3 groups： T2DM patients with microangiopathy complications group （group A, 58 cases） , T2DM patientsand without microangiopathy complications group （group B, 64 cases） microangiopathy complications and normal controls group（group C, 54 cases）.The serum TSP-1 and other clinical indicators of all the cases were detected .Use The steady -state model was used to account for the indexes of insulin resistance （HOMA- IR） and islet beta cell function index （HOMA-β）. Results The serum TSP-1 levels in type 2 diabetes with and without microangiopathy complications were significantly higher in group A and B than those in control group C（P〈0.05）. Furthermore, among type 2 diabetes,serum TSP-1 level was higher in patients with microangiopathygroup A than those withoutin group B（P〈0.05）. AThe multivariate correlation analysis showed that serum TSP-1 level positively correlates with FBGG, 、HbA1c、hs-C-RP（P〈0.01）,while negatively with HOMA-βand FINSns（P〈0.01）. Stepwise linear multiple regression revealed that HbA1Cc、FBG、HOMA-βand FINSns （P〈0.05）were the independent factors of serum TSP-1 level（P〈0.05）. Conclusion The serum TSP-1 levels is elevated in T2DM patients with microangiopathy,suggesting that it might play a role in the pathophysiology of diabetic microangiopathy,.The serum TSP-1 has and it is significant value in predicting the microangiopathy of theseT2DM patients.