高尿酸血症与缺血性脑卒中患者颈部动脉斑块及狭窄的关系

目的探讨高尿酸血症与缺血性脑卒中颈部动脉宽块之间的关系，为缺血性脑卒中的治疗提供参考方向。方法选取深圳市第六人民医院2005年1月至2008年12月缺血性脑卒中伴血尿酸升高的60例患者为研究组，并选取同期单纯缺血性脑卒中的140例患者为对照组，观察两组患者颈部动脉斑块与狭窄的情况。结果研究组颈部动脉斑块及狭窄Ⅲ级、Ⅳ级均明显高于对照组（P〈0．05）；研究组血尿酸水平高于对照组（P〈0．05）。随着颈部动脉斑块及狭窄程度的增加，患者血尿酸水平也不断升高（P〈0．05）。内中膜厚度大于或等于1．0mm患者的血尿酸水平明显高于内中膜厚度小于110mm的患者（t=11．414，P〈0．05）。结论缺血性脑卒中颈部动脉斑块、狭窄及颈动脉内中膜厚度与高尿酸血症直接有着密切的联系，并且在某种程度上血尿酸的水平能够反映出颈部动脉斑块及狭窄程度。

Relationship between hyperuricemia with carotid artery plaque and stenosis in patients with ischemic stroke

Objective To investigate the relationship between hyperuricemia with carotid artery plaques in is- chemic stroke to provide the reference direction for the treatment of this disease. Methods 60 patients with ischemic stroke complicating elevated serum uric acid in the Shenzhen Municipal Sixth People＇s Hospital from January 2005 to December 2008 were selected as the study group and contemporaneous 140 cases of simple ischemic stroke were se- lected as the control group. The carotid artery plaques and stenosis situation were observed in the two groups. Results The carotid artery plaques and stenosis grade Ⅲ, Ⅳ in the study group were significantly higher than those in the control group（P〈0.05） ;the serum uric acid levels in the study group was higher than that in the control group（P〈 0. 05）. With the increase of carotid artery plaques and stenosis degree, serum uric acid level was also continuously in- creased（P〈0.05）. Serum uric acid level in the patients with the intima-media thickness≥ 1.0nm was significantly higher than that in the patients with the intima-media thickness〈71.0mm（t= 11. 414 ,P〈0.05）. Conclusion The oc- currence of carotid artery plaques and stenosis and the intima-media thickness are directly related with hyperuricemia in ischemic stroke,the concentration value of serum uric acid can reflect the carotid artery plaques and stenosis degree to some extent.