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| 18F氟脱氧葡萄糖PET／CT评价分葱白提取物对猪缺血再灌注心肌细胞活力的影响 | |
| 引用本文： | 张介眉,柯于鹤,郝建军,夏豪,吴志坚,凃欣,王腾,吴斌,朱旭,朱浩. 18F氟脱氧葡萄糖PET／CT评价分葱白提取物对猪缺血再灌注心肌细胞活力的影响[J]. 中西医结合学报, 2009, 7(10): 947-951. DOI: 10.3736/jcim20091007 |
| 作者姓名： | 张介眉 柯于鹤 郝建军 夏豪 吴志坚 凃欣 王腾 吴斌 朱旭 朱浩 |
| 作者单位： | 1. 武汉市中西医结合医院国家中医药管理局重点研究室,湖北,武汉,430022 2. 武汉大学人民医院心内科,湖北,武汉,430060 3. 华中科技大学同济医学院协和医院PET中心,湖北,武汉,430003 4. 华中科技大学生命科学与技术学院,湖北,武汉,430074 5. 武汉大学人民医院实验中心,湖北,武汉,430060 6. 湖北省中医院心内科,湖北,武汉,430061 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的：采用18F氟脱氧葡萄糖（18F-fluorodeoxyglucose，18F-FDG）正电子发射体层扫描（position emission tomography，PET）心肌代谢显像技术评价分葱白提取物对猪缺血再灌注损伤心肌细胞活力的影响。方法：将24只猪随机分为假手术组、空白模型组、曲美他嗪组和葱白提取物组，每组6只。通过球囊封堵冠状动脉制备缺血再灌注模型。造模后第4天，葱白提取物组用葱白提取物灌胃（5.93 mg/kg，2次/d），曲美他嗪组灌胃曲美他嗪（0.36 mg/kg，2次/d），其他两组给同体积生理盐水，连续给药28 d。各组于最后一次给药后1 h行18F-FDG PET/CT心肌显像检测，采用4级评分法评价相应节段心肌细胞活力。结果：分葱白提取物与曲美他嗪均可改善缺血再灌注心肌细胞活力而保护心肌细胞，与空白模型组比较，差异有统计学意义（P〈0.01）；葱白提取物组与曲美他嗪组比较，差异无统计学意义（P〉0.05）。结论：分葱白提取物可以改善猪缺血再灌注心肌细胞活力。 |
| 关 键 词： | 心肌再灌注损伤 心肌细胞 正电子发射断层显像术 葱白提取物 曲美他嗪 猪 |
Effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swines with myocardial reperfusion injury evaluated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography |
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| Jie-mei ZHANG,Yuhe KE,Jian-jun HAO,Hao XIA,Zhi-jian WU,Xin TU,Teng WANG,Bin WU,Xu ZHU,Hao ZHU. Effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swines with myocardial reperfusion injury evaluated by 18F-fluorodeoxyglucose positron emission tomography/computed tomography[J]. Journal of Chinese integrative medicine, 2009, 7(10): 947-951. DOI: 10.3736/jcim20091007 | |
| Authors: | Jie-mei ZHANG Yuhe KE Jian-jun HAO Hao XIA Zhi-jian WU Xin TU Teng WANG Bin WU Xu ZHU Hao ZHU |
| Affiliation: | 1. Key Research Institute of the State Administration of Traditional Chinese Medicine, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan 430022, Hubei Province, China 2. Department of Cardiology, People＇s Hospital, Wuhan University, Wuhan 430060, Hubei Province, China 3. PET Center, Union Hospital. Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430003, Hubei Province, China 4. College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei Province. China 5. Experimental Center, People＇s Hospital, Wuhan University, Wuhan 430060, Hubei Province, China 6. Department of Cardiology, Hubei Provincial Hospital of Traditional Chinese Medicine. Wuhan 430061, Hubei Province, China) |
| Abstract: | Objective： To investigate the effects of extract of Bulbus Allii Caespitosi on cardiocyte viability of swines with myocardial reperfusion injury by analyzing the 18F-fluorodeoxyglucose （18F-FDG） position emission tomography （PET） imaging. Methods： Twenty-four swines were randomly divided into sham-operated group, untreated group, trimethazine group and extract of Bulbus Allii Caespitosi group. Myocardial reperfusion injury was induced by plugging the anterior descending coronary artery of swine with sacculus. Bulbus Allii Caespitosi or trimetazidine was given twice daily for 28 days. Then myocardial perfusion was detected with 18F-FDG PET/CT and the radioactivity distribution was evaluated. Results： Compared with the untreated group, Bulbus Allii Caespitosi and trimetazidine could improve the activity of myocardial cells after myocardial infarction （P〈0.01）, and there were no significant differences between Bulbus Allii Caespitosi and trimetazidine （P〉0.05）. Conclusion： Bulbus Allii Caespitosi can improve myocardial metabolism after ischemia and reperfusion in swines. |
| Keywords: | myocardial reperfusion injury myocytes, cardiac positron emission tomography Bulbus Allii Caespitosi trimetazidine swines |
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