| 益寿丸对D-半乳糖致衰老模型小鼠自由基代谢的影响 |
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| 引用本文： | 吴立蓉,吴趋凡,黄兆胜. 益寿丸对D-半乳糖致衰老模型小鼠自由基代谢的影响[J]. 现代中药研究与实践, 2012, 0(1): 31-33 |
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| 作者姓名： | 吴立蓉 吴趋凡 黄兆胜 |
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| 作者单位： | 广东药学院药用生物活性物质研究所;广东省生物活性药物研究重点实验室;广州中医药大学中药学院 |
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| 摘 要： | 目的研究益寿丸对D-半乳糖(D-gal)所致衰老小鼠自由基及免疫器官的影响,初步探讨其抗衰老的作用机制。方法采用D-半乳糖复制亚急性衰老小鼠模型。测定衰老小鼠血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、过氧化氢酶(CAT)的活性,丙二醛(MDA)的含量,以及胸腺、脾脏指数,并观察益寿丸对上述指标的影响。结果益寿丸能明显提高D-半乳糖衰老小鼠血清中SOD、GSH-PX、CAT活性,降低MDA含量,并提高胸腺、脾脏指数。结论益寿丸抗衰老作用可能与其能提高机体抗氧化酶活性,提高机体免疫功能有关。
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| 关 键 词： | 益寿丸 衰老 SOD GSH-PX CAT MDA |
Effect of Yangshou Pills on Metabolism of Free Radicals in Aging Model Mice Induced by D-galactose |
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| Affiliation: | WU Li-rong1,2,WU Qu-fan3,HUANG Zhao-shen3(1.Institute of Pharmaceutical Bioactive Substances Research,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China;2.Guangdong Provincial Key Labaratory of Pharmaceutical Bioactive Substances,Guangzhou 510006,China;3.College of Chinese Materia Medica,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China) |
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| Abstract: | Objective To study the effect of Yishou Pills on metabolism of free radicals and immune organs in subacute aging model mice induced by D-galactose.Methods Aging model in mice was established by D-galsctose(D-gal),and the activities of SOD,GSH-PX,CAT,as well as contents of MDA in serum and immune indexes were measured.Results The activities of SOD,GSH-PX,CAT were increased significantly by Yishou pills and the content of MDA in serum decreased.The spleen and the thymus index were also elevated by Yishou pills.Conclusion The anti-aging of Yishou pills could be related with scavenging free radicals and improving immune function |
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| Keywords: | Yishou pills aging SOD GSH-PX CAT MDA |
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