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| NMR确定手性α-羟基酮的绝对构型 | |
| 引用本文： | 杨春晖,陈静文,李勤,彭昆,潘鑫复,崔育新.NMR确定手性α-羟基酮的绝对构型[J].高等学校化学学报,2006,27(7):1295-1297. |
| 作者姓名： | 杨春晖 陈静文 李勤 彭昆 潘鑫复 崔育新 |
| 作者单位： | 1. 北京大学药学院,天然药物及仿生药物国家重点实验室,北京,100083 2. 兰州大学化学系,应用有机化学国家重点实验室,兰州,7300002 3. 北京大学药学院,天然药物及仿生药物国家重点实验室,北京,100083;北京大学医药卫生分析中心,北京,100083 |
| 摘 要： | 本文采用该方法将α 羟基酮分别与(R)和(S)-2-甲氧基-2-苯基-2-三氟甲基乙酸(MTPA)反应, 得到(S)和(R)-Mosher酯, 再分别测定其 1H NMR谱, 通过计算化学位移差值确定其绝对构型. |
| 关 键 词： | α-羟基酮 绝对构型 Mosher方法 核磁共振 |
| 文章编号： | 0251-0790（2006）07-1295-03 |
| 收稿时间： | 07 25 2005 12:00AM |
| 修稿时间： | 2005-07-25 |
Determination of Absolute Configuration of α-Hydroxy Ketones Using NMR |
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| YANG Chun-Hui,CHEN Jing-Wen,LI Qin,PENG Kun,PAN Xin-Fu,CUI Yu-Xin.Determination of Absolute Configuration of α-Hydroxy Ketones Using NMR[J].Chemical Research In Chinese Universities,2006,27(7):1295-1297. | |
| Authors: | YANG Chun-Hui CHEN Jing-Wen LI Qin PENG Kun PAN Xin-Fu CUI Yu-Xin |
| Affiliation: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China; 2, Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China; 3. Medical and Healthy Analysis Center, Peking University, Beijing 100083, China |
| Abstract: | In this paper a simpler Mosher′s method was developed from the modified Mosher′s method. It only need one configuration of MTPA to determine the absolute configurations of four α hydroxy ketones with their(S)-and(R)-MTPA esters using 1H NMR. The signals of protons on the same side with phenyl ring will be in the higher field than those of on the different side ones. |
| Keywords: | α-Hydroxy ketones Absolute configuration Mosher′s method NMR |
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