血清肿瘤标志物和恶性肿瘤相关因子联合检测在胃肠道肿瘤诊断中的价值

目的 探讨血清肿瘤标志物和恶性肿瘤相关因子联合测定在胃肠道恶性肿瘤诊断中的价值.方法 以胃肠道恶性肿瘤患者80例为观察组,以胃肠道良性疾病的患者50例为对照组.对两组的糖类抗原125（CA125）、糖类抗原153（CA153）、癌胚抗原（CEA）、恶性肿瘤特异性生长因子（TSGF）水平进行检测并进行统计学分析.结果 在胃肠道恶性肿瘤诊断中,联合检测的准确性为87.7%,高于各单项检测,与联合检测的准确性比较,四个单项检测（CEA、CA153、TSGF、CA125）差异均有统计学意义（X^2=3.93、4.04、3.96、3.98,均P＜0.05）.结论 血清CA125、CEA、TSGF、CA153联合检测有利于提高早期胃肠道恶性肿瘤诊断阳性率,对于早期诊断胃肠道恶性肿瘤具有一定的应用价值.

The value of testing a variety of tumor markers combined with tumor-related factors in the diagnosis of the gastrointestinal tract tumors

Objective To explore the clinical value of tumor markers and tumor-related factors in diagnosis of the gastrointestinal tract tumors.Methods 80 gastrointestinal cancer patients were treated as the observation group.And during the same period,50 patients with gastrointestinal benign disease were collected as the control group.Carbohydrate antigen （CA125）,carcinoembryonic antigen （CEA）,tumor specific growth factor （TSGF）,CA153 in two groups were detected and analyzed statistically.Results The accuracy of joint combined detection was 87.7%,which was higher than that of the individual detection.Compared with the accuracy of the combined detection,four single detections （CEA,CA153,TSGF,CA125） had a significant difference （X^2 =3.93,4.04,3.96,3.98,all P 〈 0.05）.Conclusion The joint detection of CA125,CEA,TSGF and CA153 can improve early diagnostic yield of gastrointestinal cancer.In the early diagnosis of gastrointestinal cancer this method of detection has certain guiding significance and application value in the diagnosis of gastrointestinal tract tumors.