| 骨髓间充质干细胞在胶质瘤研究中的应用 |
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| 引用本文： | 仇有成,徐建勇,王存祖.骨髓间充质干细胞在胶质瘤研究中的应用[J].国际肿瘤学杂志,2011,38(1):24-26. |
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| 作者姓名： | 仇有成 徐建勇 王存祖 |
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| 作者单位： | 江苏大学附属医院神经外科,镇江,212001 |
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| 摘 要： | 骨髓间充质干细胞(MSC)在体内具有向肿瘤部位定向迁移能力,是比较理想的基因治疗"细胞载体".通过转染或转导的方法,在体外使MSC携带目的 基因,并获得稳定表达,然后将它们移植到宿主体内,发挥治疗作用.这种先体外后体内的过程在胶质瘤等多个系统肿瘤中进行了研究,获得阳性结果.MSC移植的安全性值得关注,其中与宿主肿瘤细胞...
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| 关 键 词： | 间充质干细胞 胶质瘤 基因疗法 载体 |
Bone marrow-derived mesenchymal stem cells in treatment of gliomas |
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| QIU You-cheng,XU Jian-yong,WANG Cun-zu.Bone marrow-derived mesenchymal stem cells in treatment of gliomas[J].Journal of International Oncology,2011,38(1):24-26. |
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| Authors: | QIU You-cheng XU Jian-yong WANG Cun-zu |
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| Abstract: | Bone marrow-derived mesenchymal stem cells (MSCs) are capable of migrating and homing to brain tumors in vivo and therefore is a promising targeted-delivery vehicle in cancer gene therapy. MSCs are transfected or transducted with the therapeutic genes and achieve stable expression in vitro, then are delivered to the host to exert their therapeutic effects. The Ex Vivo gene transfer of MSCs has been studied in several types of tumors including gliomas, and results were postive. The safety of MSC-based gene delivery remains to be controversial. The interactions between MSCs and host tumor cells need to be investigated. |
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| Keywords: | Mesenchymal stem cells Gliomas Gene therapy Vehicle |
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