| 微RNA-106b～25基因簇在肿瘤中的研究进展 |
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| 引用本文： | 张安玲,浦佩玉.微RNA-106b～25基因簇在肿瘤中的研究进展[J].国际肿瘤学杂志,2011,38(3):163-165. |
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| 作者姓名： | 张安玲 浦佩玉 |
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| 作者单位： | 天津市神经病学研究所神经肿瘤室,天津医科大学总医院神经外科,300052 |
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| 基金项目： | 国家自然科学基金资助项目，天津市科技计划项目 |
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| 摘 要： | 微RNA(miRNA)-106b～25基因簇由miR-106b、miR-93及miR-25组成,与miR-17～92原癌基因簇有着极高的同源性.已有的研究表明,该簇miRNA成员在多种肿瘤中高表达.这些miR通过抑制细胞周期抑制因子p21、p57及凋亡抑制因子Bim来促进肿瘤细胞增殖,抑制细胞凋亡.在转化生长因子β(T...
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| 关 键 词： | 肿瘤 转化生长因子β 信号转导 miR-106b～25基因簇 |
Advances in study of miR-106b-25 cluster in cancer |
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| ZHANG An-ling,PU Pei-yu.Advances in study of miR-106b-25 cluster in cancer[J].Journal of International Oncology,2011,38(3):163-165. |
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| Authors: | ZHANG An-ling PU Pei-yu |
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| Abstract: | miR-106b-25 cluster is composed of miR-106b,miR-93 and miR-25,and is a paralogue of miR-17-92 cluster.Some studies have shown that the members in miR-106b-25 cluster abundantly expressed in many cancers.Over-expressions of these miRNAs promote the growth of tumor cells by negatively regulating p21 and p57,and suppress the apoptosis of tumor cells through inhibition of Bim.Moreover,high expression of miR-106b-25 cluster might endue tumor cells with resistance to inhibitory effect of cell growth induced by TGF-β signaling. |
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| Keywords: | Neoplasms Transforming growth factor beta Signal transduction miR-106b-25 cluster |
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