| 117Snm-胺基膦酸类配合物的生物分布研究 |
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| 引用本文： | 何佳恒,罗顺忠,蒲满飞,王关全,杨玉青,蒋树斌,王文进,魏洪源,邴文增. 117Snm-胺基膦酸类配合物的生物分布研究[J]. 核化学与放射化学, 2003, 25(3): 156-158,172 |
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| 作者姓名： | 何佳恒 罗顺忠 蒲满飞 王关全 杨玉青 蒋树斌 王文进 魏洪源 邴文增 |
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| 作者单位： | 中国工程物理研究院,核物理与化学研究所,四川,绵阳,621900 |
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| 基金项目： | 中国工程物理研究院军民两用基金资助项目(JM20008) |
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| 摘 要： | 为了合成具有较高骨摄取和较低血液、肌肉、脾、肺摄取的放疗药物，以用于骨癌和骨转移癌治疗，合成了4种^117Sn^m-胺基膦酸类配合物，并对其在生物体内的分布进行了比较。研究结果表明，^117Sn^m—TTHMP可望成为骨肿瘤治疗药物。
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| 关 键 词： | ^117Sn^m-胺基膦酸类配合物 生物分布 骨肿瘤 冶疗药物 表征 配体 |
| 文章编号： | 0253-9950(2003)03-0156-03 |
BIODISTRIBUTION STUDY OF 117Snm-RADIOPHARMACEUTICALS |
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| HE Jia-heng,LUO Shun-zhong,PU Man-fei,WANG Guan-quan,YANG Yu-qing,JIANG Shu-bin,WANG Wen-jin,WEI Hong-yuan,BING Wen-zengInstitute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang ,China. BIODISTRIBUTION STUDY OF 117Snm-RADIOPHARMACEUTICALS[J]. Journal of Nuclear and Radiochemistry, 2003, 25(3): 156-158,172 |
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| Authors: | HE Jia-heng LUO Shun-zhong PU Man-fei WANG Guan-quan YANG Yu-qing JIANG Shu-bin WANG Wen-jin WEI Hong-yuan BING Wen-zengInstitute of Nuclear Physics Chemistry China Academy of Engineering Physics Mianyang China |
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| Affiliation: | HE Jia-heng,LUO Shun-zhong,PU Man-fei,WANG Guan-quan,YANG Yu-qing,JIANG Shu-bin,WANG Wen-jin,WEI Hong-yuan,BING Wen-zengInstitute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang 621900,China |
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| Abstract: | The preparation and in vivo biodistribution in m ice of several 117 Sn m labelled compounds are studied. The results indicate that the favourable half-life and decay characteristics of 117 Sn m in various stannic compounds, especially stannic-TTHMP. It appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake and the binding of 117 Sn m-TTHMP to bone is higher than that of 117 Sn m-DTPA. This makes it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors. |
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| Keywords: | S n m bone tumor biodistribution |
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