| 3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯的合成 |
| |
| 引用本文： | 陶锋,吴佳,蔡春. 3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯的合成[J]. 江苏化工, 2005, 33(4): 46-47,50 |
| |
| 作者姓名： | 陶锋 吴佳 蔡春 |
| |
| 作者单位： | 1. 常州亚邦医药研究所有限公司,江苏,常州,213163
2. 南京理工大学化工学院,江苏,南京,210094 |
| |
| 摘 要： | 3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯是重要的药物中间体。以3-甲基-4-丁酰氨基苯甲酸甲酯为原料，经硝硫混酸硝化、铁粉还原得到目标化合物3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯，总收率72％。研究了硝硫混酸配比、硝化反应时间、还原反应温度、还原反应时间等因素对产物收率的影响，该工艺具有生产成本低，产品质量稳定，收率高的优点。
|
| 关 键 词： | 3-甲基-4-丁酰氨基苯甲酸甲酯 3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯 硝硫混酸 硝化 还原 |
| 文章编号： | 1002-1116（2005）04-0046-02 |
| 收稿时间： | 2005-03-02 |
| 修稿时间： | 2005-03-02 |
Synthesis of Methyl 4 - butylamino - 3 - methyl - 5 - aminobenzoate |
| |
| TAO Feng,WU Jia,CAI Chun. Synthesis of Methyl 4 - butylamino - 3 - methyl - 5 - aminobenzoate[J]. Jiangsu Chemical Industry, 2005, 33(4): 46-47,50 |
| |
| Authors: | TAO Feng WU Jia CAI Chun |
| |
| Abstract: | Methyl 4 - butyrylamino - 3 - metyl - 5 - aminobenzoate is an important pharmaceutical intermediate,and this paper presents a convenient process for its synthesis. Methyl 4 - butyrylamino - 3 - metybenzoate was nitrated with the mixture of nitric acid and sulfuric acid to afford the corresponding 5 - position nitrated compound,Reduction was performed in the presence of Fe powder, and the total yield amounted to 72%. Factors including ratio of mixed acid, nitration time, reduction temperature and reduction have been investigated, this process exhibits the advantage of low cost and high yield. |
| |
| Keywords: | methyl 4 - butyrylamino - 3 - metylbenzoate methyl 4 - butyrylamino - 3 - metyl - 5 - aminobenzoate mixed acid nitration reduction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
