卡培他滨联合吉西他滨二线方案治疗晚期转移性乳腺癌临床研究 |
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引用本文: | 张纪良,刘定义,沈诗怡,朱丽,刘鸿,曹雨晗,杨秀娟,康力. 卡培他滨联合吉西他滨二线方案治疗晚期转移性乳腺癌临床研究[J]. 西部医学, 2010, 22(11): 2009-2011 |
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作者姓名: | 张纪良 刘定义 沈诗怡 朱丽 刘鸿 曹雨晗 杨秀娟 康力 |
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作者单位: | 成都市第七人民医院肿瘤内科,四川,成都,610021 |
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摘 要: | 目的观察卡培他滨联合吉西他滨二线治疗蒽环类和(或)紫杉类耐药的晚期转移性乳腺癌患者的近期疗效及不良反应。方法卡培他滨2000 mg/m2.d,第1~14 d,每天分2次口服。吉西他滨1000 mg/m2,第1、8 d,21天为1周期。最少完成2周期,最多6周期化疗。结果 34例患者中,CR 3例(8.82%),PR 12例(35.29%),SD 11例(32.35%),PD 8例(23.53%),总有效率(CR+PR)为44.12%。结论卡培他滨联合吉西他滨二线治疗蒽环类和(或)紫杉类耐药转移性乳腺癌患者疗效较好,不良反应可以耐受。可以作为蒽环类和(或)紫杉类耐药的晚期乳腺癌患者的一个有效解救治疗方案。
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关 键 词: | 卡培他滨 吉西他滨 转移性乳腺癌 二线治疗 |
Clinical study on capecitabine and gemcitabine as second-line treatment in patients with metastatic breast cancer |
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Affiliation: | ZHANG Ji-Liang,LIU Ding-Yi,SHEN Shi-Yi,et al(Department of Medical Oncology,The Seventh People's Hospital ofChengdu,Chengdu 610021,China) |
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Abstract: | Objective To evaluate the efficacy and toxicity of the combination of capecitabine and gemcitabine as second-line treatment of anthracycline and(or) taxol resistant metastatic breast cancer patients.Methods Patients with metastatic breast cancer were treated with capecitabine 2000mg/m2/d orally bid on day 1~14 and gemcitabine 1000 mg/m2 IV on days 1 and 8 and repeated for 21 days.Results Complete remission was 3/34(8.82%) and partial remission was 12/34(35.29%).Stable disease was 11/34(32.35%) and progressive disease was 8/34(23.53%).Conclusion Combination of capecitabine and gemcitabine is an active and safe regimen as second-line therapy for anthracycline and(or) taxol resistant metastatic breast cancer.It can be a salvage treatment option for anthracycline and(or) taxo1 resistant metastatic breast cancer patients. |
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Keywords: | Capecitabine Gemcitabine Metastatic breast cancer Second-line therapy |
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