非对称富马酸二酯类的合成及对细菌的抗菌特性研究

以马来酸酐为原料先进行CnH2n+1OH（n=2～9）醇解合成马来酸单酯，然后催化转型生成富马酸单酯，再与甲醇酯化合成了一系列非对称富马酸酯类，产率85％以上．抗菌效果试验结果表明，非对称富马酸酯类可使微生物的生长适应期（t0）延长2～8倍，半对数生长期（t0.5）缩短1／3－2／3，相对生长量降低75％以上，生长势（t0．5／t0）仅为对照的1／28～1／6，并可显著地诱导和促进微生物菌群的自溶作用．

Study on methyl n-alkyl famarates preparation and its antibacterial activity

Methyl n-alkyl ethys, propyl, butyl, amyl, nonyl, famarates were preparated,the yields were over 85%. These diesters could effectively prolong adaptive phose (t0) ofbacteria from deteriorate ham sauage for 2-8 times, shorten the half logarithmic growth phase(t0.5) to 1/3-2/3, t0.5/t0 values were ouly 1/28-1/6 of the control. methy n-alkyl famaratessignificantly inhibited the growth and induced the autolysis of bacteria.