| 大鼠品系及药物剂量对糖尿病大鼠模型的影响 |
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| 引用本文： | 陈枫,程锦楠,唐小平,李艳,王小燕.大鼠品系及药物剂量对糖尿病大鼠模型的影响[J].泸州医学院学报,2011,34(2):156-158. |
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| 作者姓名： | 陈枫 程锦楠 唐小平 李艳 王小燕 |
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| 作者单位： | 泸州医学院附属医院感染与免疫研究室,四川,泸州,646000 |
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| 摘 要： | 目的：通过一次性注射链脲佐菌素（STZ）制作大鼠糖尿病模型,观察大鼠品系、给药剂量对大鼠成模率、死亡率的影响。方法：Wistar、SD大鼠雄性各50只,随机分组为正常对照和剂量组（STZ1组：55mg/kg,2组：45 mg/kg,3组：35 mg/kg,4组：25 mg/kg）,腹腔注射STZ,48小时后观察血糖,8周后计算死亡率,病理切片观察胰岛细胞。结果：Wistar、SD大鼠55mg/kg组全部成模,死亡率分别是100%、90%;45 mg/kg组全部成模,死亡率40%、28%;35 mg/kg组成模率为100%、30%,零死亡;25 mg/kg组成模率为70%、0%,零死亡。结论：35mg/kg剂量Wistar大鼠,成模率高,死亡率低,且结果优于SD大鼠。
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| 关 键 词： | 链脲佐菌素 糖尿病 成模 大鼠 |
EFFECTS OF STREPTOZOCIN DOSAGE AND THE STRAINS OF RATS ON ESTABLISHING DIABETES MELLITUS ANIMAL MODEL |
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| Chen Feng,et al Research Room of Infection , Immunology,The Affiliated Hospital of Luzhou Medical College.EFFECTS OF STREPTOZOCIN DOSAGE AND THE STRAINS OF RATS ON ESTABLISHING DIABETES MELLITUS ANIMAL MODEL[J].Journal of Luzhou Medical College,2011,34(2):156-158. |
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| Authors: | Chen Feng Research Room of Infection Immunology The Affiliated Hospital of Luzhou Medical College |
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| Affiliation: | Chen Feng,et al Research Room of Infection and Immunology,The Affiliated Hospital of Luzhou Medical College |
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| Abstract: | Objective:To investigate the effects of streptozocin(STZ) dosage and the strains of rats on the incidence and mortality of diabetes mellitus animal model.Methods:50 Wistar male rats and 50 SD male rats were randomly divided into normal control group and dose group;dose group were injected intraperitoneally with different dose of STZ(group 1,STZ 55mg/kg,group 2,STZ 45 mg/kg,group 3,STZ 35 mg/kg,group 4,STZ 25 mg/kg).Then,the blood glucose was measured after 48 hours,calculating mortality and to observe patho... |
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| Keywords: | Streptozotocin Diabetes mellitus DM model establishment Rat |
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