持续肝癌介入治疗与介入治疗后手术切除的疗效对比

目的探讨持续肝癌介入治疗与介入治疗后再行手术切除的临床疗效。方法选取青岛市中心医院2008年1月-2010年1月收治的原发性肝癌患者86例,采用随机数字法分为对照组和观察组,每组43例,对照组采用动脉栓塞持续介入治疗,观察组采用动脉栓塞介入治疗后再行手术切除治疗,比较两组患者治疗的临床疗效。结果观察组的病灶根除率、术后生存率、术后丙氨酸氨基转移酶(ALT)峰值、术后天冬氨酸氨基转移酶(AST)峰值均明显高于对照组(P0.05),术后复发率、并发症发生率均明显低于对照组,复发患者平均生存期明显长于对照组,差异均有统计学意义(P0.05)。结论动脉栓塞介入治疗后再行手术切除的临床疗效明显优于动脉栓塞持续介入治疗,病灶根除干净,术后复发率低,生存期较长,远期效果较好,值得临床推广使用。

Comparative study of continuous interventional therapy and operation resection after interventional therapy in the treatment of hepatocellular carcinoma

Objective To investigate clinical efficacy of continuous interventional therapy and operation resection after interventional therapy in treatment of hepatocellular carcinoma.Methods Eighty-six patients with primary liver cancer in Central Hospital of Qingdao City from Jan.2008 to Jan.2010 were selected,and randomly divided into control group and observation group.Patients in control group were given interventional therapy of arterial embolism sustained and patients in observation group were treated with operation resection after interventional therapy of arterial embolism.The clinical efficacy was compared between two groups.Results Focus eradication rate,postoperative survival rate,postoperative peak value of alanine aminotransferase （ALT） and as partate aminotramsferase （AST） in the observation group were significantly higher than that in the control group （P ＜ 0.05）.Postoperative recurrence rate and complication rate in the observation group were significantly lower than those in the control group.Mean survival time of patients with recurrent in the observation group was significantly longer than that in the control group.Differences were statistically significant （P ＜ 0.05）.Conclusion Clinical effect of operation resection after interventional therapy in arterial embolism is obviously superior to interventional therapy of arterial embolism sustained.Postoperative recurrence rate is lower.Survival period is longer.Kong-term effect is better.That is worth for clinical use.