| 功能磁共振用于肿瘤光热和光动力协同治疗的实时监测研究 |
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| 引用本文： | 曹健波,付贵峰,张 帆,刘 刚.功能磁共振用于肿瘤光热和光动力协同治疗的实时监测研究[J].福州大学学报(自然科学版),2015,43(5):722-726. |
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| 作者姓名： | 曹健波 付贵峰 张 帆 刘 刚 |
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| 作者单位： | 厦门大学公共卫生学院分子影像暨转化医学研究中心, 福建 厦门 361102,厦门大学公共卫生学院分子影像暨转化医学研究中心, 福建 厦门 361102,厦门大学公共卫生学院分子影像暨转化医学研究中心, 福建 厦门 361102,厦门大学公共卫生学院分子影像暨转化医学研究中心, 福建 厦门 361102 |
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| 摘 要： | 将实验动物分为光热治疗组、光动力治疗组、光热和光动力协同治疗组,使用T2加权和扩散加权两种磁共振成像方式对治疗效果进行实时监测,并使用病理学方法对磁共振检测效果进行验证.实验结果发现,两个单纯治疗组中肿瘤并未被完全杀灭;而协同治疗组中,肿瘤被完全杀灭.磁共振作为无创监测手段,在疗效评价中有巨大的应用价值,并可对纳米粒子的设计合成起到指导作用.
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| 关 键 词： | 功能磁共振 光热治疗 光动力治疗 实时监测 |
Real-time monitoring of tumor response to photothermal/photodynamic therapy by functional magnetic resonance imaging |
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| CAO Jianbo,FU Guifeng,ZHANG Fan and LIU Gang.Real-time monitoring of tumor response to photothermal/photodynamic therapy by functional magnetic resonance imaging[J].Journal of Fuzhou University(Natural Science Edition),2015,43(5):722-726. |
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| Authors: | CAO Jianbo FU Guifeng ZHANG Fan and LIU Gang |
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| Affiliation: | Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China,Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China,Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China |
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| Abstract: | Measurement of tumor microenvironment by magnetic resonance imaging (MRI) is a valuable technique for noninvasive monitoring of tumor development and its response to treatment strategies. This paper assess the long-term curative effect of tumor after different treatment strategies. Compared with photodynamic therapy or photothermal therapy alone, the combined therapy showed a significantly synergistic effect, which was demonstrated by functional MRI. The results provide a direct, non-invasive method for in vivo monitoring of the treatment response to nanoparticle-mediated PTT, which can be used to guide cancer therapy to improve potential clinical outcomes. |
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| Keywords: | functional MRI photothermal therapy photodynamic therapy real-time monitoring |
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