| 超声介导DNA门控空心介孔二氧化硅纳米粒的药物释放 |
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| 引用本文： | 何敏瑜,冉海涛,马明,贾晓庆,王志刚. 超声介导DNA门控空心介孔二氧化硅纳米粒的药物释放[J]. 中国医学影像技术, 2015, 31(2): 191-195 |
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| 作者姓名： | 何敏瑜 冉海涛 马明 贾晓庆 王志刚 |
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| 作者单位： | 重庆医科大学超声影像学研究所, 重庆 400010;重庆医科大学超声影像学研究所, 重庆 400010;重庆医科大学附属第二医院超声科, 重庆 400010;中国科学院上海硅酸盐研究所, 上海 200050;中国科学院上海硅酸盐研究所, 上海 200050;重庆医科大学超声影像学研究所, 重庆 400010 |
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| 基金项目： | 重庆市高校创新团队计划(KJTD201303)、国家自然基金重点项目(81130025) |
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| 摘 要： | 目的制备一种DNA门控的空心介孔二氧化硅纳米粒(HMSNs-DNA),观察其体外超声显像及高强度聚焦超声(HIFU)刺激触发药物释放效果。方法采用碳二亚胺法连接HMSNs和DNA制备HMSNs-DNA,检测其理化性质。体外观察HMSNs-DNA的超声成像效果。将阿霉素作为模型药物载于HMSNs-DNA纳米粒,体外运用HIFU辐照,观察其药物释放效果。结果制备的DNA门控的空心介孔二氧化硅纳米粒呈球形;随着HMSNs-DNA纳米粒浓度的增大,其超声信号强度逐渐增强;经HIFU辐照后阿霉素释放明显增强。结论成功制备DNA门控的介孔二氧化硅纳米粒,具有良好超声成像效果,并可响应HIFU刺激促发药物定位释放。
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| 关 键 词： | 空心介孔二氧化硅 脱氧核糖核酸 超声处理 造影剂 药物释放 |
| 收稿时间： | 2014-08-30 |
| 修稿时间： | 2014-12-12 |
Ultrasound triggered drug delivery by DNA gated hollow mesoporous silica nanoparticles |
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| HE Min-yu,RAN Hai-tao,MA Ming,JIA Xiao-qing and WANG Zhi-gang. Ultrasound triggered drug delivery by DNA gated hollow mesoporous silica nanoparticles[J]. Chinese Journal of Medical Imaging Technology, 2015, 31(2): 191-195 |
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| Authors: | HE Min-yu RAN Hai-tao MA Ming JIA Xiao-qing WANG Zhi-gang |
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| Affiliation: | Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, China;Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, China;Department ofUltrasonography, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China;Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China;Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China;Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, China |
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| Abstract: | Objective To prepare a DNA gated hollow mesoporous silica nanoparticles (HMSNs-DNA), and to observe its ultrasonic imaging in vitro and the effect of drug release by high intensity focused ultrasound (HIFU) triggering. Methods DNA gated hollow mesoporous silica nanoparticles were prepared by carbodiimide technique. Physical and chemical properties and ultrasound imaging were tested. Loading of Doxorubicin hydrochloride (DOX) in the nanoparticles, after using HIFU, the release effect was observed. Results DNA gated hollow mesoporous silica nanoparticles were spherical. The ultrasonic signal intensity enhanced with HMSNs-DNA concentration increased in vitro. After using HIFU, the release of the DOX enhanced obviously. Conclusion DNA gated hollow mesoporous silica nanoparticles which can act as ultrasonic contrast agent is successfully prepared, and the drug positioning release can be markedly improved by HIFU in vitro. |
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| Keywords: | Hollow mesoporous silica DNA Sonication Contrast media Drug delivery |
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