应用EDI-OCT 检测NAION患者脉络膜厚度的研究

目的：评价利用光学相干断层扫描增强深部成像(enhanced depth imaging optical coherence tomography，EDI-OCT)测量非动脉炎性前部缺血性视神经病变(nonarteritic anterior ischemic optic neuropathy， NAION)脉络膜厚度的临床意义。

方法：选取2014-12/2016-10门诊就诊的NAION患者(对侧眼未受累)共30例30眼，选取与病例组性别、年龄、屈光度相匹配的正常对照组60例60眼，应用EDI-OCT分别测量患病眼、对侧眼及对照组右眼的脉络膜厚度。

结果：患病组与对照组相比，年龄、性别、屈光度无统计学差异(P>0.05)。经统计学检验，患病眼、对侧眼中心凹附近及视盘盘周各部位脉络膜厚度均小于对照组，差异有统计学意义(P<0.01)，而患病眼与对侧眼脉络膜厚度比较差异无统计学意义(P>0.05)。

结论：NAION患者患病眼、对侧眼脉络膜厚度较正常对照组明显减低，提示睫状后短动脉小血管的阻塞可能影响脉络膜的血供，进而影响脉络膜厚度。

Choroidal thickness in nonarteritic anterior ischemic optic neuropathy measured by enhanced depth imaging OCT

AIM: To observe the choroidal thickness in nonarteritic anterior ischemic optic neuropathy(NAION)measured by enhanced depth imaging optical coherence tomography(EDI-OCT)and evaluate its clinical significance.

METHODS: Totally 30 patients diagnosed with NAION were studied and 60 individuals with normal fundus were set as control. Choroidal thickness was measured by EDI-OCT. Choroidal thickness of the affected eye and contralateral eye in patient group and right eye of the control group were evaluated and recorded.

RESULTS: Differences in age, gender and refractive status between NAION group and control were not significant(P>0.05). Choroidal thickness near fovea and optic disc in affected eye and contralateral eye in patient group was thinner compared to these of control group(P<0.01). No statistical differences were observed in the choroidal thickness between affected eye and contralateral eye(P>0.05).

CONCLUSION: In NAION patients, choroidal thickness of affected eyes and unaffected contralateral eyes were significantly thinner compared to these of control group. Diminish of the observed choroidal thickness in this study might be explained by small vessels occlusion in posterior ciliary artery, which would affect the blood supply of the choroid.