氨氯地平-阿托伐他汀复合制剂在心血管疾病治疗中的应用

高血压和血脂异常均为心血管疾病的主要危险因素。氨氧地平是常用的第3代钙通道阻滞药,阿托伐他汀是常用的甲基羟戊二酰辅酶A还原酶抑制剂。氨氯地平-阿托伐他汀复合制剂是2药固定剂量的单一制剂,除降低血压和调脂作用外,氨氯地平和阿托伐他汀联合应用尚有改善血管内皮功能、抗炎症、抗动脉粥样硬化、改善血管顺应性、减少左室肥厚、改善胰岛素敏感性等作用。临床研究表明氨氯地平和阿托伐他汀复合制剂具有疗效显著、依从性好、可降低心血管事件发生、不良反应少而轻微等优点。

Use of amlodipine-atorvastatin compound in treatment of cardiovascular diseases

Both hypertension and dyslipidaemia are main risk factors of cardiovascular diseases.Amlodipine is a commonly used third generation calcium channel antagonist.Atorvastatin is a commonly used HMG-CoA reductase inhibitor.Amlodipine-atorvastatin compound is a single-tablet,fixed-dose combination of 2 drugs.In addition to decrease blood pressure and treat dyslipidaemia,amlodipine and atorvastatin combination may also has the function of improving vascular endothelial function,anti-inflammation,anti-atherosclerosis,improving vascular compliance,decreasing left ventricular hypertrophy and improving insulin sensitivity.The clinical studies showed that amlodipine-atorvastatin compound had the advantage of high efficacy,better compliance, few and mild adverse reactions and may decrease the cardiovascular endpoint.