四川南充地区2型糖尿病合并肾病流行状况及危险因素

目的四川南充地区2型糖尿病合并肾病的流行状况及危险因素。方法回顾分析南充地区192例2型糖尿病肾脏病患者(研究组)和224例单纯2型糖尿病(对照组),比较两组一般资料及实验室检查结果,采用logistic回归分析探讨危险因素。结果2型糖尿病患者中合并肾脏病的患者共353例,发病率为13.46%。糖尿病肾脏病组的吸烟饮酒比例、BMI、空腹血糖、糖化血红蛋白、总胆固醇、肌酐及血尿酸水平均高于单纯糖尿病组。糖尿病肾脏病组病程长于单纯糖尿病组。糖尿病病程、吸烟史、BMI、糖化血红蛋白、总胆固醇及血尿酸是2型糖尿病肾脏病的独立危险因素。结论糖尿病肾脏病的发生发展是病程、吸烟、肥胖、血糖控制差、总胆固醇、血尿酸多种因素相互作用的结果。早期检测和控制危险因素能够延缓糖尿病肾脏病的进展。

Study on the epidemic status and risk factors of type 2 diabetes mellitus complicated with nephropathy in Nanchong,Sichuan

Objective To explore and analyze the risk factors of type 2 diabetes with kidney disease in Nanchong,Sichuan.Methods A retrospective analysis of 192 cases of type 2diabetic nephropathy(study group)and 224 cases of simple type 2 diabetes(control group)in Nanchong area was conducted.The general data and laboratory test results of the two groups were compared,and logistic regression analysis was used to explore the risk factors.Results In this study,there were a total of 353 patients with type 2diabetes complicated with kidney disease,and the incidence rate was 13.46%.The proportion of smoking and drinking,BMI,fasting blood glucose,glycosylated hemoglobin,total cholesterol,creatinine and blood uric acid in the diabetic nephropathy group were higher than those in the simple diabetes group.The course of disease in the diabetic nephropathy group was longer than that in the simple diabetes group.Course of diabetes,smoking-history,BMI,glycosylated hemoglobin,total cholesterol,and serum uric acid were independent risk factors for type 2 diabetic kidney disease.Conclusion The occurrence and development of diabetic kidney disease is the result of the interaction of multiple factors such as the disease course,smoking,obesity,poor blood glucose control,total cholesterol and serum uric acid.Early detection and control of risk factors can delay the progression of diabetic kidney disease.