| 肝硬化湿热瘀毒郁结复合病机的理论及临床应用研究 |
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| 作者姓名： | 叶放 周静汶 皇金萍 王盼盼 王振 吴婉琳 张婷婷 周仲瑛 |
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| 作者单位： | 南京中医药大学第一临床医学院，江苏 南京 210023 |
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| 摘 要： | 探讨了肝硬化湿热瘀毒郁结复合病机理论的科学内涵与临床应用，认为湿热瘀毒复合病机是肝硬化进程演化中的核心病机，瘀热是肝硬化湿热瘀毒郁结复合病机中的关键环节。并对肝硬化湿热瘀毒郁结复合病机的现代医学病理生物学基础进行了探讨，提出了清化湿热瘀毒法辨治肝炎-肝纤维化-肝硬化的临床思路，揭示了清化湿热瘀毒法对肝硬化形成和加重过程中免疫及炎症反应网络的多环节调控作用机理，为中医病机理论的创新研究提供示范。
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| 关 键 词： | 肝硬化 湿热瘀毒郁结 瘀热 复合病机 理论基础 临床应用 |
Scientific Connotation and Clinical Application of the Compound Pathogenesis of Hepatocirrhosis Characterized by Constraint of Dampness-Heat and Stasis-Toxin |
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| Authors: | YE Fang ZHOU Jing-wen HUANG Jin-ping WANG Pan-pan WANG Zhen WU Wan-lin ZHANG Ting-ting ZHOU Zhong-ying |
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| Abstract: | The paper discussed the scientific connotation and clinical application of the compound pathogenesis of hepatocirrhosis characterized by constraint of dampness-heat and stasis-toxin. Constraint of dampness-heat and stasis-toxin was regarded as the core pathogenesis， and stasis-heat was the key link. Besides， we explored the patho-biological basis of the compound pathogenesis in modern medicine， proposed the clinical thought of clearing and removing dampness-heat and stasis-toxin， disclosed the mechanisms of regulating immune and inflammatory symptomatic response network during the progress of hepatocirrhosis with clearing and removing therapy， and provided a demonstration for the innovative research of the pathogenesis theory in traditional Chinese medicine. |
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| Keywords: | hepatocirrhosis constraint of dampness-heat and stasis-toxin stasis-heat compound pathogenesis theoretical fundament clinical application |
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