人精子中尿激酶型纤溶酶原激活因子及其受体的分布

本文采用免疫组化和免疫电镜法研究了正常健康男子精子中尿激酶型纤溶酶原激活因子（ｕＰＡ）及其受体（ｕＰＡＲ）的分布。结果表明ｕＰＡ主要分布在顶体内外膜和头部浆膜上；精子尾部浆膜也含有ｕＰＡ；在ｕＰＡ出现的部位同时也发现有ｕＰＡＲ存在。推测结合在精子受体膜上的ｕＰＡ可能在精子的运行、精液的液化和受精过程中发挥重要的作用。

The Immunohistochemical Localization of Urokinase -type Plasminogen Activator(uPA) and Urokinase-type Plasminogen Activator Receptor(uPAR)in Human Spcrmatozoa

This paper focuses on the distribution of urokinase-type plasminogen activator(uPA) and urokinase-type plasminogen activator receptor(uPAR).uPA and uPAR were determined in the ejaculated spermatozoa of healthy men by immunohistochemistry and immunoelectron microscopy. Based on these findings it was suggested that uPA was distributed in the outer and inner acrosomal membrane and the plasma membrane of the head of the spermatozoa.The plasma membrane of spermatozoa tail contained uPA.The uPAR was found in the position where uPA was located in the membrane of the spermatozoa.It was suggested that sperm-bound uPA on the uPAR could play an important role in spermatozoa motility,semen liquefaction and fertilization.All of these factors are known to play an active role in human reproduction.