| 基于非独占式并行计算技术的ChIP-on-chip芯片分析平台 |
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| 引用本文： | 杨旭智,石建涛,韩蓓蓓,王萍,王健,张济,王侃侃. 基于非独占式并行计算技术的ChIP-on-chip芯片分析平台[J]. 计算机应用与软件, 2009, 26(8): 10-13 |
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| 作者姓名： | 杨旭智 石建涛 韩蓓蓓 王萍 王健 张济 王侃侃 |
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| 作者单位： | 上海大学生命学院,上海,200444;上海交通大学医学院瑞金医院医学基因组学国家重点实验室,上海,200025;上海交通大学医学院瑞金医院医学基因组学国家重点实验室,上海,200025;上海大学生命学院,上海,200444 |
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| 基金项目： | 国家自然科学基金项目，国家高科技研究发展项目 |
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| 摘 要： | 随着"后基因组时代"的到来以及各种高通量组学技术的发展,ChIP-on-chip这一新兴的研究细胞内蛋白质与全基因组DNA之间调控机制的实验技术已逐渐成熟并推广.然而由此产生的海量数据也给生物学意义的整合与数据挖掘带来了严峻的挑战.针对ChIP-on-chip得到的高通量原始实验数据,探索如何更有效地开展研究工作,实现了由分析模块、监控模块、并行框架三个模块构建的自适应并行计算系统.系统能非独占式地充分利用计算机资源计算,自动生成富集的DNA序列片段并将其映射到基因组用于后续分析;可比较分析多次实验以评估实验条件、分析不同转录因子之间的协同作用等;其包含的监控模块、并行框架很容易移植入其他开发过程.
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| 关 键 词： | ChIP-on-chip 并行计算 系统监控 |
CHIP-ON-CHIP ANALYSIS PLATFORM BASED ON NON-EXCLUSIVE PARALLEL COMPUTING TECHNIQUE |
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| Yang Xuzhi,Shi Jiantao,Han Beibei,Wang Ping,Wang Jian,Zhang Ji,Wang Kankan. CHIP-ON-CHIP ANALYSIS PLATFORM BASED ON NON-EXCLUSIVE PARALLEL COMPUTING TECHNIQUE[J]. Computer Applications and Software, 2009, 26(8): 10-13 |
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| Authors: | Yang Xuzhi Shi Jiantao Han Beibei Wang Ping Wang Jian Zhang Ji Wang Kankan |
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| Affiliation: | School of Life Science;Shanghai University;Shanghai 200444;China;State Key Laboratory of Medical Genomics;Ruijin Hospital;School of Medicine;Shanghai Jiaotong University;Shanghai 200025;China |
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| Abstract: | With the emergence of post-genomic era and the new developments in high-throughput "-omics" technology in recent years,the ChIP-on-chip technique,which is an emerging experimental technique aims to study regulatory mechanisms between proteins and genome-wide DNA under different cellular conditions,is becoming more mature and to be growingly used.However,the mass of experimental data resulted has brought with it serious challenges in terms of integration and data mining with biological significance.Aiming at... |
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| Keywords: | ChIP-on-chip |
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