药物介导的自噬改变对肿瘤细胞放射敏感性的影响

放射治疗诱导的自噬与导致细胞死亡的凋亡起到的作用不同，其具有既可以导致细胞死亡又可以保护细胞生存的双重性。自噬这一过程在放射治疗和辐射毒性中的抗肿瘤效应还不明确。一系列药物试验已经证实诱导或者抑制自噬，直接影响细胞毒性和放射治疗的效果，同时发生的目标性自噬和凋亡似乎进一步增强了放射治疗的抗肿瘤效应。本文就调节放射诱导的自噬在肿瘤细胞中作用的研究进展进行简要综述。

Influence of change in drug-mediated autophagy level on the radiosensitivity of tumor cells

Experimental results demonstrate that radiation-induced autophagy, a major pathway, which is differ-ent from apoptosis that leads to cells death, may lead to either death or survival. The role of autophagy in the antitumor effect of radiotherapy and in radiation toxicity is still obscure. A series of research have proved that inducing and block-ing autophagy directly interfers with cytotoxicity and effect of radiotherapy. Simultaneous autophagy and apoptosis dur-ing radiotherapy seems to enhance the therapeutic effect. This review summarizes the up-to-date findings on the func-tions of regulating autophagic response of cancer cells to radiotherapy.