Direct HPLC resolution of beta-aminoalcohol (tazifylline,ranolazine, sotalol) enantiomers |
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| Authors: | E Delée L Le Garrec I Jullien S Béranger J C Pascal H Pinhas |
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| Affiliation: | (1) Recherche Syntex France, Leuville-Sur-Orge, 91310 Montlhéry, France |
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| Abstract: | Summary A routine chiral analysis has been developed to control the optical purity of chiral drugs and to monitor their asymmetric
synthesis. The recent advent of new chiral stationary phases for HPLC enabled us to achieve the direct resolution of chiral
drugs without any derivatization.
The factors affecting chiral resolution on a new alpha1-acid glycoprotein column (EnantioPac, LKB) were assessed with three beta-aminoalcohols. |
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| Keywords: | Direct HPLC Enantiomers Resolution Beta-aminoalcohols |
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