| 固有免疫分子DC-SIGN在幽门螺杆菌感染胃黏膜上皮细胞表达意义 |
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| 引用本文： | 林凯,曾敬清,刘伟,杨芬,袁菲,赵蔚,郭晓奎,周同,许春娣. 固有免疫分子DC-SIGN在幽门螺杆菌感染胃黏膜上皮细胞表达意义[J]. 现代免疫学, 2011, 0(2): 101-106 |
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| 作者姓名： | 林凯 曾敬清 刘伟 杨芬 袁菲 赵蔚 郭晓奎 周同 许春娣 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院儿科;上海交通大学医学院附属瑞金医院病理科;上海交通大学医学院病原生物学教研究室; |
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| 基金项目： | 国家自然科学基金资助项目(30770999、81000163); 上海市科委基础研究重点项目基金资助项目(09JC1409900) |
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| 摘 要： | 探讨固有免疫分子DC-SIGN在幽门螺杆菌(H.pylori)感染的胃上皮细胞表达,及其与胃黏膜损伤的关系.选取经胃镜及组织病理检查确诊的72例慢性胃炎患儿胃黏膜活检标本,采用免疫组化检测胃黏膜上皮细胞DC-SIGN表达.体外建立幽门螺杆菌感染胃上皮细胞模型,采用流式细胞术检测幽门螺杆菌刺激的胃上皮细胞DC-SIGN以...
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| 关 键 词： | 幽门螺杆菌 胃黏膜炎症 胃上皮细胞 DC-SIGN 免疫调节 |
Expression of DC-SIGN on gastric epithelial cells in Helicobacter pylori infection |
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| LIN Kai,ZENG Jing-qing,LIU Wei,YANG Fen,YUAN Fei,ZHAO Wei,GUO Xiao-kui,ZHOU Tong,XU Chun-di. Expression of DC-SIGN on gastric epithelial cells in Helicobacter pylori infection[J]. Current Immunology, 2011, 0(2): 101-106 |
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| Authors: | LIN Kai ZENG Jing-qing LIU Wei YANG Fen YUAN Fei ZHAO Wei GUO Xiao-kui ZHOU Tong XU Chun-di |
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| Affiliation: | LIN Kai1,ZENG Jing-qing1,LIU Wei1,YANG Fen1,YUAN Fei2,ZHAO Wei3,GUO Xiao-kui3,ZHOU Tong1,XU Chun-di1(1.Department of Pediatrics,Ruijin Hospital Affiliated to Jiaotong University School of Medicine,Shanghai 200025,China,2.Department of Pathology,3.Department of Medical Microbiology and Parasitology,Shanghai Jiaotong University School of Medicine,China) |
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| Abstract: | To explore the expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin(DC-SIGN)on gastric epithelial cell during H.pylori infection and its possible immunomodulatory effects in the pathology of gastric mucosal lesion.The expression of DC-SIGN on gastric epithelial cells was examined by immunohistochemistry in 72 gastric mucosal biopsies of patients with chronic gastritis confirmed by upper endoscopy and histology.In vitro,the expressions of DC-SIGN,CD80 and CD86 on gast... |
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| Keywords: | Helicobacter pylori gastric mucosal inflammation gastric epithelial cells DC-SIGN immunoregulation. |
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