| 碱性成纤维细胞生长因子与垂体腺瘤增殖及侵袭能力的关系 |
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| 引用本文： | 文路,陈凌,刘运生. 碱性成纤维细胞生长因子与垂体腺瘤增殖及侵袭能力的关系[J]. 中南大学学报(医学版), 2001, 26(5): 466-468 |
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| 作者姓名： | 文路 陈凌 刘运生 |
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| 作者单位： | 中南大学湘雅医院神经外科 |
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| 摘 要： | 利用免疫组织化学方法检测 5 1例人类垂体腺瘤标本的碱性成纤维细胞生长因子 (bFGF)与增殖细胞核抗原 (PCNA)蛋白表达。结果显示 ,在 2 9例 (5 6 9% )垂体腺瘤标本中检测到bFGF呈中等强度以上的阳性表达 ;bFGF表达水平与PCNA标记指数呈正相关 ;在无功能腺瘤中 ,bFGF的表达与肿瘤侵袭性相关 ,但在激素分泌性腺瘤中两者相关性不明显。提示bFGF可能参与了垂体腺瘤的增殖过程及部分腺瘤的侵袭过程。
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| 关 键 词： | 垂体腺瘤 碱性成纤维细胞因子 免疫组织化学 |
| 文章编号： | 1000-5625(2001)-05-0466-03 |
| 修稿时间： | 2000-10-10 |
Relationship between basic fibroblast growth factor (bFGF) and cell proliferation, invasion in pituitary adenoma |
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| WEN Lu,CHEN Ling,LIU Yun sheng. Relationship between basic fibroblast growth factor (bFGF) and cell proliferation, invasion in pituitary adenoma[J]. Journal of Central South University. Medical sciences, 2001, 26(5): 466-468 |
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| Authors: | WEN Lu CHEN Ling LIU Yun sheng |
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| Affiliation: | (Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China) |
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| Abstract: | Basic fibroblast growth factor (bFGF) and proliferating cell nuclear antigen (PCNA) were examined by immunohistochemistry in fifty-one pituitary adenomas. The results showed that the intensity of bFGF expression was strong or intermediate in twenty-nine adenomas, which was positively related to cell proliferation, there was positive relationship between bFGF expressin and tumor invasion in non-functional adenomas. The data suggest that bFGF may play some role in the origin and progression of pituitary adenomas. |
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| Keywords: | pituitary adenoma basic fibroblast growth factor (bFGF) * immunohistochemistry |
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