DMSO increases radioiodination yield of radiopharmaceuticals. |
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| Authors: | Ketai Wang S James Adelstein Amin I Kassis |
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| Affiliation: | Department of Radiology, Armenise Building Room D2-137, 200 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA. |
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| Abstract: | A high-yield radioiodination method for various types of molecules is described. The approach employs DMSO as precursor solvent, a reaction ratio of 2-5 precursor molecules per iodine atom, 5-10 microg oxidant, and a 10-25 microl reaction volume. The solution is vortexed at room temperature for 1-5 min and progress of the reaction is assessed by HPLC. Radioiodinated products are obtained in > or = 95% yield and meet the requirements for radiotracer imaging, biodistribution studies, and molecular and cellular biology research. |
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