五子衍宗汤治疗Leber遗传性视神经病变的临床研究

目的 观察中药五子衍宗汤对Leber遗传性视神经病变 (Leber hereditary optic neuropathy，LHON)的治疗作用。方法 将符合观察要求的30例LHON患者分为治疗组和对照组，治疗组口服五子衍宗汤及辅酶Q₁₀片，对照组仅口服辅酶Q₁₀片，疗程均为90天。观察治疗前后患者视力、视野、视觉诱发电位变化。结果 治疗前后治疗组视力、视野、视觉诱发电位有一定程度改善；对照组视力改善，但视野、视觉诱发电位未见改善。组间比较，治疗组视力、视野、视觉诱发电位改善更明显。结论 五子衍宗汤对LHON具有一定的临床治疗作用。

Clinical Study on Treatment of Leber Hereditary Optic Neuropathy by Wuzi Yanzong Decoction

Objective To investigate the effect of Wuzi Yanzong Decoction (WYD) in treating Leber hereditary optic neuropathy (LHON). Methods Thirty patients of LHON up to the requirement were assigned to two groups, the treated group administered with WYD plus coenzyme Q_(10), and the control group with coenzyme Q_(10) alone, all for 3 months. Patients' visual acuity, visual field, vision evoked potential (VEP) and their Chinese medicine syndrome were observed before and after treatment. Results After treatment, all the above-mentioned indexes were improved to some extents in the treated group, but showed no evident change in the control group excepting visual acuity, comparison between groups showed the differences were significant in all items. Conclusion WYD shows certain clinical therapeutic effect for treatment of LHON.