| THE ESTABLISHMENT OF A NEW ANIMAL MODEL FOR GASTRIC CANCER STUDY BY ORTHOTO PIC IMPLANTATION OF GASTRIC CANCER CELLS INTO ATHYMIC NUDE MICE |
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| 作者姓名： | 曾知真 施尧 萧树东 江绍基 张素胤 殳裕华 |
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| 作者单位： | Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Materia Medica，the Chinese Academy of Sciences，Shanghai，Shanghai Institute of Materia Medica，the Chinese Academy of Sciences，Shanghai |
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| 基金项目： | This work was supported by grant from the Chinese National Natural Science Foundation |
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| 摘 要： | An animal model mimicking human gastric cancer by gastric wall implantation technique in athymic nude mice was reported. Two human gastric cancer cell lines. MKN-45 and MKN-28, were used in this study. All animals with gastric wall implantation of cancer cells of these two cell lines developed grossly visible gastric tumors after 3-4 weeks of implantation. Histopathological examination showed that tumors prirnarily grew at serosal side of stomach, and progressively invaded the gastric mucosa, but none showed metastasis in this study. All tumor-bearing animals died within 5-8 weeks after implantation. These results indicated that gastric wall of nude mice provided a good soil for growth and propagation of human gastric cancer cells. The model was useful for in vivo study on biological behavior of various types of human gastric cancers.
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THE ESTABLISHMENT OF A NEW ANIMAL MODEL FOR GASTRIC CANCER STUDY BY ORTHOTO PIC IMPLANTATION OF GASTRIC CANCER CELLS INTO ATHYMIC NUDE MICE |
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| Zeng Zhizhen Shi Yao Xiao Shudong Jiang Shaoji.THE ESTABLISHMENT OF A NEW ANIMAL MODEL FOR GASTRIC CANCER STUDY BY ORTHOTO PIC IMPLANTATION OF GASTRIC CANCER CELLS INTO ATHYMIC NUDE MICE[J].Journal of Shanghai Second Medical University(Foreign Language Edition),1992(1). |
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| Authors: | Zeng Zhizhen Shi Yao Xiao Shudong Jiang Shaoji |
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| Affiliation: | Zeng Zhizhen Shi Yao Xiao Shudong Jiang Shaoji Shanghai Institute of Digestive Disease,SSMU,Shanghai Zhang Suyin Shu Yuhua Shanghai Institute of Materia Medica,the Chinese Academy of Sciences,Shanghai |
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| Abstract: | An animal model mimicking human gastric cancer by gastric wall implantation technique in athymic nude mice was reported. Two human gastric cancer cell lines. MKN-45 and MKN-28, were used in this study. All animals with gastric wall implantation of cancer cells of these two cell lines developed grossly visible gastric tumors after 3-4 weeks of implantation. Histopathological examination showed that tumors prirnarily grew at serosal side of stomach, and progressively invaded the gastric mucosa, but none showed metastasis in this study. All tumor-bearing animals died within 5-8 weeks after implantation. These results indicated that gastric wall of nude mice provided a good soil for growth and propagation of human gastric cancer cells. The model was useful for in vivo study on biological behavior of various types of human gastric cancers. |
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| Keywords: | stomach neoplasm animal model athymic nude mouse tumor implantation |
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