| 川芎嗪对免疫介导骨髓衰竭小鼠肾脏氧化应激的影响 |
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| 引用本文： | 张小敏,高磊,胡潇,聂玲辉,陈育尧,莫志贤,朱玲玲. 川芎嗪对免疫介导骨髓衰竭小鼠肾脏氧化应激的影响[J]. 中国药理学通报, 2019, 0(11): 1570-1574 |
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| 作者姓名： | 张小敏 高磊 胡潇 聂玲辉 陈育尧 莫志贤 朱玲玲 |
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| 作者单位： | 1.南方医科大学中医药学院;2.南方医科大学南方医院中医科;3.广东省传统医学与运动伤害康复研究所 |
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| 基金项目： | 国家自然科学基金资助项目(No 81573706) |
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| 摘 要： | 目的 探讨川芎嗪(tetramethylpyrazine,TMP)对免疫介导的骨髓衰竭(BMF)小鼠肾脏氧化应激的影响。方法 将C57小鼠随机分成正常对照组、单纯辐照组(TBI)、模型组、TMP低剂量组(5 g·L -1 )、TMP中剂量组(10 g·L -1 )、TMP高剂量组(20 g·L -1 )。C57小鼠经5.0 Gy X射线全身辐照和淋巴细胞输注,建立BMF模型。观察14 d后小鼠外周血三系细胞、骨髓有核细胞、骨髓病理学、肾脏病理学及氧化应激等指标。结果 模型组骨髓病理显示有核细胞减少,外周血三系明显降低,说明成功建立免疫介导BMF模型;模型组肾脏病理显示肾小管水肿,氧化应激指标MDA升高,抗氧化应激指标GSH、SOD、GSH-Px下降,提示BMF小鼠肾脏存在氧化应激损伤。经TMP治疗后,肾脏病理未见明显异常,肾脏中MDA下降及GSH、SOD上升,免疫组化结果显示,HIF-1α表达下降,并出现VEGF表达。结论 TMP可减轻免疫介导的BMF小鼠肾脏氧化应激损伤,可能与调节HIF-1α/VEGF表达有关。
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| 关 键 词： | 重型再生障碍性贫血 骨髓衰竭 X射线 川芎嗪 肾脏 氧化应激 |
Effect of tetramethylpyrazine on renal oxidative stress in immune-mediated bone marrow failure mice |
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| ZHANG Xiao-min,GAO Lei,HU Xiao,NIE Ling-hui,CHEN Yu-yao,MO Zhi-xian,ZHU Ling-ling. Effect of tetramethylpyrazine on renal oxidative stress in immune-mediated bone marrow failure mice[J]. Chinese Pharmacological Bulletin, 2019, 0(11): 1570-1574 |
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| Authors: | ZHANG Xiao-min GAO Lei HU Xiao NIE Ling-hui CHEN Yu-yao MO Zhi-xian ZHU Ling-ling |
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| Affiliation: | (College of Traditional Chinese Medicine, Nanfang Hospital,Southern Medical University, Guangzhou 510515, China;Dept of Traditional Chinese Medicine, Nanfang Hospital,Southern Medical University, Guangzhou 510515, China;Guangdong Institute of Traditional Medicineand Sports Injury Rehabilitation, Guongzhou 510317, China) |
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| Abstract: | ZHANG Xiao-min;GAO Lei;HU Xiao;NIE Ling-hui;CHEN Yu-yao;MO Zhi-xian;ZHU Ling-ling(College of Traditional Chinese Medicine, Nanfang Hospital,Southern Medical University, Guangzhou 510515, China;Dept of Traditional Chinese Medicine, Nanfang Hospital,Southern Medical University, Guangzhou 510515, China;Guangdong Institute of Traditional Medicineand Sports Injury Rehabilitation, Guongzhou 510317, China) |
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| Keywords: | severe aplastic anemia bone marrow failure X-ray tetramethylpyrazine kidney oxidative stress |
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