自体血穴位注射治疗糖尿病胃轻瘫的疗效观察及对血浆胃动素、胃泌素的影响

目的:观察自体血穴位注射治疗糖尿病胃轻瘫的疗效并初步探讨其机制。方法:将42例患者随机分为治疗组和对照组,治疗组取足三里、中脘、胃俞自体血穴位注射,对照组口服吗丁啉;两组患者治疗前及治疗4周后采用放射免疫法检测血浆胃动素、胃泌素含量,评定疗效,观察治疗中的不良反应,监测病情的复发情况。结果:治疗组总有效率71.4%(15/21),对照组总有效率33.3%(7/21),其疗效差异有统计学意义(P<0.05);两组治疗后血浆胃动素、胃泌素水平较治疗前均明显降低(P<0.01),治疗组降低较对照组更明显(P<0.01);治疗组不良反应少于对照组,复发率明显低于对照组(P<0.01)。结论:自体血足三里、中脘、胃俞穴位注射可以明显改善糖尿病胃轻瘫病人症状,其机制可能与降低血浆胃动素及胃泌素有关。

Effects of acupoint injection of autologous blood on symptoms and plasma motilin and gastrin levels of diabetic gastroparesis patients

Objective To observe the curative effect of autologous blood point injection on diabetic gastroparesis and to study its underlying mechanism.Methods A total of 42 type-Ⅱ diabetes outpatients and inpatients were randomly and equally divided into treatment group and control group according to a random digit table.Patients of the treatment group were treated by injection of the patient’s own venous blood(2 mL/acupoint)into the unilateral Zusanli(ST 36),Zhongwan(CV 12)and Weishu(BL 21),once every week,4 times together.Patients of the control group were ordered to take motilium(10 mg/time),3 times daily for 4 weeks.Plasma motilin and gastrin were detected by radioimmunoassay before and 4 weeks after the treatment.Results Of the two 21 cases in the control and treatment groups,3 and 7 experienced marked improvement in their symptoms,4 and 8 were effective,14 and 6 were failed in the treatment,with the effective rates being 33.3% and 71.4% respectively.The effective rate of the treatment group was significantly higher than that of the control group(P<0.05).The contents of plasma motilin and gastrin in both control and treatment groups were reduced obviously after the treatment(P<0.01),and the effect of the treatment group was significantly superior to that of the control group in lowering plasma motilin and gastrin levels(P<0.01).Conclusion Acupoint injection of the diabetes patients’ own blood can obviously alleviate the symptoms of diabetic gastroparesis,which is closely associated with its effects in lowering plasma motilin and gastrin levels.