| 蒿甲虚热清颗粒解热作用及机制研究 |
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| 引用本文： | 江涛,唐春萍,曾昭智,张锦红,陈艳芬.蒿甲虚热清颗粒解热作用及机制研究[J].广东药学院学报,2010,26(4):384-387. |
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| 作者姓名： | 江涛 唐春萍 曾昭智 张锦红 陈艳芬 |
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| 作者单位： | 1. 广东药学院,实验动物中心，广东,广州,510006
2. 广东药学院,中药学院,广东,广州,510006 |
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| 摘 要： | 目的探讨蒿甲虚热清颗粒的解热作用及机制。方法采用家兔阴虚热盛证模型和酵母混悬液复制大鼠发热模型,观察蒿甲虚热清颗粒的解热作用,并采用放射免疫法测定下丘脑中cAMP含量的变化。结果蒿甲虚热清颗粒对家兔阴虚热盛证模型和酵母混悬液复制大鼠发热模型的动物体温升高有明显的抑制作用,并能抑制下丘脑中cAMP含量的增高。结论蒿甲虚热清颗粒有明显的解热作用,其机制可能与其减少下丘脑cAMP生成与释放有关。
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| 关 键 词： | 蒿甲虚热清 解热 cAMP |
A study on the antipyretic effects and mechanism of Haojia Xureqing granules |
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| JIANG Tao,TANG Chun-ping,ZENG Zhao-zhi,ZHANG Jin-hong,CHEN Yan-fen.A study on the antipyretic effects and mechanism of Haojia Xureqing granules[J].Academic Journal of Guangdong College of Pharmacy,2010,26(4):384-387. |
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| Authors: | JIANG Tao TANG Chun-ping ZENG Zhao-zhi ZHANG Jin-hong CHEN Yan-fen |
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| Affiliation: | 1.Laboratory Animal Center; 2.School of Traditional Chinese Medicine,Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China) |
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| Abstract: | Objective To explore the antipyretic effects of Haojia Xureqing granules and the mechanism of the antipyretic effects. Methods Rabbit model of extreme heat due to deficiency of yin and rat fever model induced by subcutaneous injection of beer yeast suspension were used,the antipyretic of Haojia Xureqing granules was observed,and variations of cAMP level in hypothalamus was determined with radioimmunoassay.Results Intragastric administration with Haojia Xureqing granules showed obvious inhibitive effects on temperature elevation in the rabbit model of extreme heat due to deficiency of yin and rat fever model induced by subcutaneous injection of beer yeast suspension,and inhibited the increasing of cAMP level in hypothalamus.Conclusion Haojia Xureqing granules had significant antipyretic effects,and the mechanism might be related to the generation and release of cAMP in hypothalamus. |
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| Keywords: | cAMP |
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