^32P胶体与无水乙醇介入性超声治疗甲状腺结节对比研究

目的 评价^32P胶体与无水乙醇介入性超声治疗甲状腺良性结节的疗效差异。方法 超声介入32P胶体局部注射治疗甲状腺良性结节的患者124例，无水乙醇治疗122例。3个月和12个月后评价两种方法的疗效。结果 无水乙醇硬化及^32P治疗甲状腺良性结节均有明显的效果，3个月和12个月的总有效率分别为91．8％和93．4％，91．9％和96．8％，两者差异无显著性（P〉0．05）；其中，囊性病变疗效好于实性病变，3个月总的有效率分别为100％和73．8％（P〈0．01）。^32P胶体治疗实性病变稍优于无水乙醇治疗，两者3个月有效率分别为79．5％和69．4％，差异有显著性（P〈0．05）；对于囊性病变，两种治疗的效果差异无显著性（P〉0．05）。结论 ^32P胶体与无水乙醇介入性超声治疗甲状腺良性结节均有良好的效果，^32P胶体治疗实性病变效果更好。

Comparative observation on the effect of interventional ultrasound therapy and phosphate- 32 colloid and ethnol injection on thyroid benign nodules

Objective To evaluate the therapeutic effects of radioactive colloidal chromiun phosphated- 32 and Percutancous ethnol interventional ultrasound therapy on patients with thyroid benign nodules. Methods There 124 patients with thyroid benign nodules were treated with radioactive colloidal chromiun phosphated- 32 （RCCP） and 122 patients treated with Percutaneous ethnol injection（PEI） under the guidance of ultrasound. The therapeutic results were evaluated 3 months and 12 months after treatment. Results ①Both radioactive colloidal chromiun phosphate- 32 and ethnol showed significant effects in reducing the size of the nodules and the total effective rates were 91.0%, 93.4% and 91.9%, 96.8% 3 and 12 months after treatment respectively, without significant difference （ P 〉 0.05）. But the effect on cyst lesions was better than that on solid lesion with the total effective rates of 100% and 73.8% respectively 3 months after treatment （ P 〈 0.01）. ②The effect of PEI on solid lesion was superior than that of RCCP with the effective rates of 79.5% and 69.4% （ P 〈 0.05）. Conclusion Both interventional ultrasound therapy with radioactive colloidal chromiun phosphated- 32 and Percutaneous ethnol are effective for treatment of thyroid benign nodules and the effect of the former on patients with solid nodules is better than that of the latter.