Isolation of a polymorphic CA repeat sequence at the human progesterone receptor (PGR) locus |
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| Authors: | Kazuhiro Tsukamoto Ikuyo Watanabe Tadayoshi Shiba M Emi |
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| Affiliation: | (1) Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki, 211-8533 Japan Tel. +81-44-733-5230; Fax +81-44-733-5192 e-mail: memi@nms.ac.jp., JP;(2) Department of Molecular Biology, Faculty of Science, Kitasato University, Sagamihara, Japan, JP |
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| Abstract: | We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the human progesterone receptor
(PGR) gene. This polymorphism will be a useful marker in the genetic study of disorders affecting female endocrine systems,
such as progesterone resistance and breast, uterine, and ovarian cancers.
Received: July 27, 1998 / Accepted: July 29, 1998 |
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| Keywords: | Progesterone receptor CA repeat Progesterone resistance Pseudocorpus luteum insufficiency Female endocrine system |
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