| 硫酸镁对大鼠继发性脊髓损伤保护作用的实验研究 |
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| 引用本文： | 王鑫渊,刘维钢,杜鹏.硫酸镁对大鼠继发性脊髓损伤保护作用的实验研究[J].石河子大学学报,2009,27(4):478-481. |
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| 作者姓名： | 王鑫渊 刘维钢 杜鹏 |
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| 作者单位： | 王鑫渊,杜鹏(石河子大学医学院,石河子,832002);刘维钢(乌鲁木齐兵团医院,乌鲁木齐,830002) |
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| 摘 要： | 为探讨硫酸镁对大鼠继发性脊髓损伤的保护作用及机制.用30只体重280±20g wister成年大白鼠随机分为三组:A组(对照组),仅行T10阶段椎板减压;B组(损伤组),C组(治疗组),均行T10阶段椎板减压和Allen's重物打击致脊髓损伤,伤后30min时B组腹腔注射蒸馏水1600mg/kg,C组腹腔注射硫酸镁1600m//kg.48h后切去伤段脊髓组织分别测定H2O、Ca2+、Mg2+离子含量,观察局部组织病理学改变,超微结构及单位面积的凋亡细胞数.结果显示跟A组比较,B、C组损伤段脊髓组织H2O、ca2+含量增多,Mg2+含量减少,组织病理学及超微结构破坏严重,凋亡细胞数升高,而且C组较B组轻.由此可知,病程早期应用硫酸镁可以减轻脊髓损伤后的继发性损伤,从而对受损脊髓起到保护作用.
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| 关 键 词： | 硫酸镁 脊髓损伤 凋亡细胞 |
Experimental Study of Protective Effect of Magnesium Sulfate on Secondary Spinal Cord Injury in Rats |
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| WANG Xinyuan,LIU Weigang,DU Peng.Experimental Study of Protective Effect of Magnesium Sulfate on Secondary Spinal Cord Injury in Rats[J].Journal of Shihezi University(Natural Science),2009,27(4):478-481. |
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| Authors: | WANG Xinyuan LIU Weigang DU Peng |
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| Affiliation: | 1 Medicine College of Shihezi University;Shihezi 832002;2 Bingtuan Hospital of Wulumuqi;830002 |
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| Abstract: | objective to discuss the possible mechanism of protective effects of magnesium sulfate on the injuried spinal cord in rats model.Thirty WisterRats were randomly divided into 3 groups:group A(Normal group);group B (Spinal cord injury) that is SCI;group C(Treatment group):SCI with magnesium sulfate treatment.The SCI Animals model was made by using an improved Allen's weight-drop device.After thirty minutes the animals of group B were injected with 1600mg/kg distilled water through Abdominal cavity injection a... |
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| Keywords: | magnesium sulfate Spinal cord injury apoptosis cell |
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