| 硝酸咪康唑脂质体的制备工艺研究 |
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| 引用本文： | 靖会,刘凌之,张宇洁,边军昌. 硝酸咪康唑脂质体的制备工艺研究[J]. 现代医药卫生, 2011, 27(4): 491-492 |
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| 作者姓名： | 靖会 刘凌之 张宇洁 边军昌 |
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| 作者单位： | 1. 西安医学院药学院,陕西,西安,710021
2. 第四军医大学唐都医院药剂科,陕西,西安,710038 |
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| 基金项目： | 西安医学院校级课题(0518) |
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| 摘 要： | 目的:探讨硝酸咪康唑脂质体的制备工艺.方法:以包封率和载药量为指标,应用正交试验法优选最佳制备工艺.结果:最佳工艺处方为乙醇注入法,药脂比3%(w/w),磷脂与胆同醇的摩尔比为80:20,缓冲液pH7.4.制备的脂质体包封率为75.54%,平均粒径为222.3 nm,zeta电位为-0.31mV.结论:乙醇注入法制备硝酸咪康唑脂质体包封率高.制备工艺合理、可行.
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| 关 键 词： | 硝酸咪康唑 脂质体 制备工艺 正交试验 |
Study on preparation technology of miconazole nitrate liposome |
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| JING Hui,LIU Ling-zhi,ZHANG Yu-jie,et al.. Study on preparation technology of miconazole nitrate liposome[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2011, 27(4): 491-492 |
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| Authors: | JING Hui LIU Ling-zhi ZHANG Yu-jie et al. |
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| Affiliation: | JING Hui1,LIU Ling-zhi2,ZHANG Yu-jie1,et al.(1.Department of Pharmacy,Xi'an Medical College,Xi'an,Shaanxi 710021,China,2.Department of Pharmacy,Tangdu Hospital,Fourth Military Medical University,Shaanxi 710038,China) |
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| Abstract: | Objective:To study the preparation technology of miconazole nitrate 1iposome.Methods:The process technology was optimized through orthogonal design analysis with entrapment efficiency and drug loading as indexes.Results:The method of ethanol injection was chosen as the preferable method,and the ratio of drug to membrane material was 3%(w/w),the mole ratio of phospholipid to cholesterol was 80:20,pH of the buffer solution was 7.4.For the prepared liposome by optimized formulation and process,the entrapment r... |
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| Keywords: | Miconazole nitrate Liposome Preparation technology Orthogonal design |
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