| 黄芪丹参复方成分对一氧化氮合成阻滞孕鼠胎盘滋养细胞单核细胞趋化蛋白mRNA表达的影响 |
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| 引用本文： | 王若光,尤昭玲,陈学东,李春梅,贺福元,刘小丽,刘惠萍. 黄芪丹参复方成分对一氧化氮合成阻滞孕鼠胎盘滋养细胞单核细胞趋化蛋白mRNA表达的影响[J]. 中草药, 2005, 36(5): 723-726 |
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| 作者姓名： | 王若光 尤昭玲 陈学东 李春梅 贺福元 刘小丽 刘惠萍 |
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| 作者单位： | 湖南中医学院,中西医结合系,湖南,长沙,410007 |
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| 基金项目： | 国家自然科学基金资助项目(30000225)，国家中医药管理局基础项目(2000-J-T-17)，湖南省教委青年资助项目(01B014) |
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| 摘 要： | 目的研究黄芪丹参复方成分提高胎盘血供的分子机制,为临床有效防治胎盘血供不足所致妊娠并发症提供思路。方法提取分离黄芪丹参复方有效成分,运用一氧化氮合酶(NO S)阻滞剂L-精氨酸甲酯(L-NAM E)制备一氧化氮合成阻滞大鼠模型,核酸原位杂交法检测胎盘局部滋养细胞单核细胞趋化蛋白-1(M CP-1)mRNA表达的变化。结果一氧化氮合成阻滞模型组滋养细胞M CP-1 mRNA表达染色明显增强,空白组、黄芪丹参复方成分治疗组及硝酸甘油对照组均能减弱M CP-1 mRNA的表达,与模型组比较差异显著(P<0.01)。结论黄芪丹参复方成分降低母胎界面妊娠免疫反应,阻抑胎盘免疫病理损伤,可能与抑制M CP-1 mRNA表达及母胎界面炎性细胞游走、浸润有关,是其能够提高胎盘血液供应的机制之一。
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| 关 键 词： | 妊娠 一氧化氮 滋养细胞 单核细胞趋化蛋白-1 黄芪 丹参 胎盘 |
| 文章编号： | 0253-2670(2005)05-0723-04 |
| 收稿时间： | 2004-11-19 |
Effect of components in Radix Astragli-Radix Salviae Mil Tiorrhizae Compound on expression of monocytic chemotactic protein mRNA on placental trophocyte of nitrogen oxide synthesis blocking pregnant rats |
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| WANG Ruo-guang,YOU Zhao-ling,CHEN Xue-dong,LI Chun-mei,HE Fu-yuan,LIU Xiao-li and LIU Hui-ping. Effect of components in Radix Astragli-Radix Salviae Mil Tiorrhizae Compound on expression of monocytic chemotactic protein mRNA on placental trophocyte of nitrogen oxide synthesis blocking pregnant rats[J]. Chinese Traditional and Herbal Drugs, 2005, 36(5): 723-726 |
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| Authors: | WANG Ruo-guang YOU Zhao-ling CHEN Xue-dong LI Chun-mei HE Fu-yuan LIU Xiao-li LIU Hui-ping |
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| Affiliation: | Department of Integrated Traditional Chinese and Western Medicine, Hunan Collegeof Traditional Chinese Medicine, Changsha 410007, China;Department of Integrated Traditional Chinese and Western Medicine, Hunan Collegeof Traditional Chinese Medicine, Changsha 410007, China;Department of Integrated Traditional Chinese and Western Medicine, Hunan Collegeof Traditional Chinese Medicine, Changsha 410007, China;Department of Integrated Traditional Chinese and Western Medicine, Hunan Collegeof Traditional Chinese Medicine, Changsha 410007, China;Department of Integrated Traditional Chinese and Western Medicine, Hunan Collegeof Traditional Chinese Medicine, Changsha 410007, China;Department of Integrated Traditional Chinese and Western Medicine, Hunan Collegeof Traditional Chinese Medicine, Changsha 410007, China;Department of Integrated Traditional Chinese and Western Medicine, Hunan Collegeof Traditional Chinese Medicine, Changsha 410007, China |
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| Abstract: | |
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| Keywords: | pregnancy nitrigen oxide (NO) trophocyte monocytic chemotactic protein-1 (MCP-1) Radix Astragli Radix Salviae Mil Tiorrhizae placenta |
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