大肠癌术前放免治疗及化疗与肿瘤坏死的相关性研究

】 ObjectiveTo study theinfluence of preoperative radioimmunotherapy and chemotherapy (or targeting chemotherapy)on neoplsatic cells of colorectal carcinoma (CRC). MethodsSixty-threepatients were divided into five groups.Group A (16 cases) had been injected with anti-CEAmonoclonal antibody,C50-¹³¹I conjugates with mitomycin C,at tumor location forpreoperative radioimmunotherapy.Group B (10 cases) had been injected with ¹³¹Iat tumor location before operation.Group C (7 cases) had received preoperative i.v.mitomycin for chemotherapy. Group D (13 cases) had recived preoperative i.v. targetingchemotherapy with CEA-mitomycin. Group E (17 patients) had not received any preoperativeanti-tumor medication. The tumors of all patients were resected. The resected specimenswere assessed by histologic examination. ResultsIn group A,there were2 cases in 1st grade,10 cases in 2nd grade and 4 cases in 3rd grade necrosis of tumortissue.In group B,6 cases in 1st grade, 4 cases in 2nd grade and no cases in 3rd gradenecrosis.In group C,2 cases in 1st grade,5 cases in 2nd grade necrosis.In group D, 2 in1st grade,7 in 2nd and 4 in 3rd grade necrosis.But in group E,all resected tumor tissuesof 17 patients were in 1st grade necrosis. Conclusion① Preoperativeradioimmunotherapy,chemotherapy (or tageting chemotherapy) and preoperative injection ofradioisotope ¹³¹I could cause necrosis of tumor tissue.② It was considered tobe useful using preoperative treatment to colorectal carcinoma.

Correlativity of preoperative therapy with necrosis of tumor tissue in colorectal carcinoma