吡柔比星在膀胱原位癌定位诊断中的应用

目的 探讨吡柔比星在膀胱原位癌(CIS)定位诊断中的效果.方法 在经尿道膀胱肿瘤电切(TUR-BT)术前膀胱内灌注吡柔比星(THP),术中在普通膀胱镜下能清楚地看见肿瘤组织及周围部分膀胱黏膜组织被染色,分别切除并送检.结果 在15例移行细胞癌患者中,11例于肿瘤周边区域或膀胱其他部位均发现有小的橙色区域.这些组织电切病理结果:2例移行细胞癌,3例原位癌,2例不典型增生,4例慢性膀胱炎.肿瘤旁未染色的膀胱粘膜组织病理切片均未发现膀胱尿路上皮癌.结论 通过经尿道膀胱肿瘤电切术前灌注吡柔比星,能肉眼发现膀胱微小癌灶及原位癌,方便而快速,能较好的指导电切,对减少肿瘤的遗漏有较大的临床意义.

Diagnosing the Location of Carcinoma in situ (CIS) of the Urinary Bladder Using Pirarubicin Hydrochloride

Objectives To discuss the effect of pirarubicin hydrochloride(THP) on niveau diagnosis of bladder carcinoma in situ( CIS).Methods We dissolved 50 mg of THP in 50 ml of distilled water,and instilled the resulting solution into the urinary bladder.After 5 min,the urinary bladder is examined using a cystoscope.The study group consisted of 15 subjects.Results THP uptake was seen in 11 flat ( nontumorous) areas of the bladder mucosa in 11 patients.Of these,11 lesions in 3 patients were confirmed to be CIS.THP uptake was also seen in flat malignant lesions such as bladder cancer invasion into the prostatic urethra,and in benign lesions such as chronic cystitis and urothelial hyperplasia.Conclusions The present method can be useful to fi nd easily and macroscopically the location of flat malignant lesions such as CIS.