| 阿霉素耐药株及维拉帕米逆转后的GST活性变化 |
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| 引用本文： | 刘岳彪,尹勇.阿霉素耐药株及维拉帕米逆转后的GST活性变化[J].肿瘤基础与临床,1994(4). |
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| 作者姓名： | 刘岳彪 尹勇 |
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| 作者单位： | 北京北太平路医院肿瘤研究中心 |
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| 摘 要： | 我们通过测定Ｐ３８８／ＡＤＲ及Ｌ１２１０／ＤＤＰ抗药株ＧＳＴ活性表明：Ｐ３８８／ＡＤＲ耐药株ＧＳＴ活性分别为敏感株的１．３６（耐药８．７倍）和１．７３倍（耐药４４．４倍），顺铂耐药株ＧＳＴ活性为敏感株的１．２６倍，ＶＰ使耐药株ＧＳＴ活性增加１．１９倍。表明阿霉素耐药与ＧＳＴ活性增强有关。
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| 关 键 词： | 阿霉素，药物耐药性，GST活性 |
The GST Activity in P388/ADR Resistant Lines and P388/ADR Reversed by Verapamil |
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| Liu Yuebiao, et al.The GST Activity in P388/ADR Resistant Lines and P388/ADR Reversed by Verapamil[J].journal of basic and clinical oncology,1994(4). |
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| Authors: | Liu Yuebiao |
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| Abstract: | The level of glutathione transferase activity was determined in the whole cell extracts. It showed a 1. 36 and 1. 73-fold increase in GST enzymic activity in Adr-resistant P388 ascites cells (8. 7 and 44. 4-fold) (P<0. 01). whereas the L1210/DDP (cis-platinum resistant lines) increased 1. 26-fold in enzyme activity in resistant cells. It also showed a 1. 19-fold increase in GST activity in P388/ADR reversed by verapamil. |
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| Keywords: | Adriamycin Drug Reesistance Glutathione-s-transferases |
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