甲苯达唑药盐防治钩虫病的研究

1984～1987年,在广西壮族自治区5401人口范围内,用甲苯达唑伴食盐(简称药盐)供全民服用。平均每人每天服甲苯达唑40mg,连服15～20d后,钩虫卵阴转率为92.3～94.4％;50、100和200mg/d×30d各剂量组的钩虫卵阴转率均达100％。试点居民服2个疗程后钩虫感染率从原来的57.9～71.1％下降到1％以下。上述一次剂量蛔虫卵阴转率高达99.1～100％;100mg/d×30d的鞭虫卵阴转率为97.6％。药盐副反应轻微,无需药物处理。

Mebendazole-medicated-salt in the control of hookworm infection

From 1984-1987, mass application of mebendazole-medicated salt was studied for the control of hookworm infection in 5 pilot areas (Wuming, Shanlin, Bobai, Guilin and Rongxian Counties) in Guangxi Zhuang Autonomous Region. The dosages of mebendazole (mixed with salt) administered were 15mg, 25mg, 30mg, 40mg, 50mg, 30mg, 70mg, 80mg, 100mg or 200mg per person per day for 15, 20 or 30 days. The results showed that 40mg/day for 15-20 days could result in stool egg negative conversion rates of 92.3 to 94.4%, while 50mg/day for 30 days resulted in 96.9 to 100%. Concurrently, the hookworm infection rate in pilot areas dropped by 57.9-71.7% in a short time; whereas the stool egg negative conversion rate of Ascaris lumbricoides was as high as 99.1% to 100% at the same dosage, when the dosage of 100mg/day for 30 days was given, the egg negative reversion rate for Trichuris trichiura was 97.6%. Promising result was also recorded concerning the tolerance of the medicated salt, as the side effects in the inhabitants were mild. In conclusion, the authors considered that the application of mebendazole-medicated salt was a simple and effective measure in controlling hookworm infection, especially in the light of solving the problem of incomplete mass detection and selected mass treatment. Furthermore, it is much more economic from the cost-effect point of view.