| Phen-Fe_3O_4/PLA-PEG-PLA微球的制备、表征及体外释放行为 |
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| 引用本文： | 李亚瑜,毛晓颖,汪凌,甄卫军.Phen-Fe_3O_4/PLA-PEG-PLA微球的制备、表征及体外释放行为[J].材料导报,2012,26(8):85-88,101. |
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| 作者姓名： | 李亚瑜 毛晓颖 汪凌 甄卫军 |
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| 作者单位： | 新疆大学化学化工学院,乌鲁木齐,830046 |
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| 基金项目： | 2005年度新疆维吾尔自治区高校科研计划(XJEDU2005E01) |
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| 摘 要： | 采用微波合成的PLA-PEG-PLA和单微乳法制备的纳米Fe3O4为载体,以邻菲罗啉(1,10-Phenanthro-line,Phen)为释放模型药物,通过乳化-溶剂挥发法制备了Phen-Fe3O4/PLA-PEG-PLA微球。通过傅里叶变换红外光谱(FT-IR)、核磁共振波谱(1 H-NMR)、X射线衍射(XRD)、扫描电子显微镜(SEM)对PLA-PEG-PLA及磁性微球的结构进行了表征分析。结果表明,微波法合成的PLA-PEG-PLA是一种三嵌段共聚物,载药微球呈规则球形,表面光滑,粒径分布较均匀。体外释放行为表明PLA-PEG-PLA作为载药基质具有明显的缓释性能。
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| 关 键 词： | PLA-PEG-PLA 微波合成 邻菲罗啉 纳米四氧化三铁 载药微球 药物释放 |
Preparation, Characterization and in Vitro Release Behavior of Phen-Fe3O4/PLA-PEG-PLA Microspheres |
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| LI Yayu
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MAO Xiaoying
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WANG Ling
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ZHEN Weijun.Preparation, Characterization and in Vitro Release Behavior of Phen-Fe3O4/PLA-PEG-PLA Microspheres[J].Materials Review,2012,26(8):85-88,101. |
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| Authors: | LI Yayu MAO Xiaoying WANG Ling ZHEN Weijun |
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| Affiliation: | (College of Chemistry & Chemical Engineering,Xinjiang University,Urumqi 830046) |
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| Abstract: | Phen-Fe3O4/PLA-PEG-PLA-MS was prepared by emulsion-solvent evaporation method with PLA-PEG-PLA synthesized by microwave-assisted polymerization and nano-Fe3O4 synthesized by water-in-oil single microemulsion(one reactant) processing as drug carriers,1,10-Phenanthroline(Phen)as model drug.The microstructure of PLA-PEG-PLA and drug-loaded microspheres were characterized and analyzed by FT-IR,1H-NMR,XRD and SEM.It was shown that PLA-PEG-PLA was of triblock copolymer.Microspheres were more regular and smooth.Its size distribution was uniformity.The study in vitro release behavior showed that PLA-PEG-PLA as a drug-loading matrix had obvious sustained-release property. |
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| Keywords: | PLA-PEG-PLA microwave-assisted polymerization 1 10-phenanthroline nano-Fe3O4 drug-loa-ded microspheres drug release |
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