| 黄芪和硫酸锌对肠缺血-再灌注致肺损伤的防治作用 |
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| 引用本文： | 段国贤,景有伶,赵春秀,胡泊,李宏杰,胡永奇,张连元. 黄芪和硫酸锌对肠缺血-再灌注致肺损伤的防治作用[J]. 天津医药, 2005, 33(1): 36-38 |
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| 作者姓名： | 段国贤 景有伶 赵春秀 胡泊 李宏杰 胡永奇 张连元 |
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| 作者单位： | 063000,唐山,华北煤炭医学院 |
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| 基金项目： | 河北省煤炭厅基金资助项目(项目编号:961416004517) |
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| 摘 要： | 目的：研究黄芪、硫酸锌对肠缺血-再灌注(I／R)过程中肺脂质过氧化变化的影响并探讨其机制。方法：采用夹闭兔肠系膜上动脉及松央再灌注，复制损伤模犁。将动物随机分成4组，观察黄芪、硫酸锌对人、出肺血及肺组织超氧化物歧化酶(SOD)、黄嘌呤氧化酶（XO)、丙二醛(MDA)及肺表面活性物质(PS)含量的影响。结果：肠I／R过程中伴有急性肺损伤，静脉给予黄芪及硫酸锌可使再灌注后XO及MDA含量降低，且可防止SOD和PS减少。结论：黄芪、硫酸锌通过抗脂质过氧化能减轻或住一定程度上防止急性肺损伤的发生和发展。
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| 关 键 词： | 黄芪 肠缺血-再灌注 硫酸锌 急性肺损伤 防治作用 抗脂质过氧化 肠系膜上动脉 过程 结论 目的 |
Preventive and Therapeutic Effect of Astragalus and Zinc Sulfate on Lung Injury During Intestinal Ischemia-Reperfusion (I/R) Injury |
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| DUAN Guoxian,JING Youling,ZHAO Chunxiu,HU Bo,LI Hongjie,HU Yongqi,ZHANG Lianyuan North China Coal Mining Medical College,Tangshan ,China. Preventive and Therapeutic Effect of Astragalus and Zinc Sulfate on Lung Injury During Intestinal Ischemia-Reperfusion (I/R) Injury[J]. Tianjin Medical Journal, 2005, 33(1): 36-38 |
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| Authors: | DUAN Guoxian JING Youling ZHAO Chunxiu HU Bo LI Hongjie HU Yongqi ZHANG Lianyuan North China Coal Mining Medical College Tangshan China |
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| Affiliation: | DUAN Guoxian,JING Youling,ZHAO Chunxiu,HU Bo,LI Hongjie,HU Yongqi,ZHANG Lianyuan North China Coal Mining Medical College,Tangshan 063000,China |
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| Abstract: | Objective: To investigate the preventive and therapeutic effects of astragalus and zinc sulfate on lung injury during intestinal ischemia-reperfusion (I/R) and to study their mechanism as well. Methods: Models of intestinal I/R injury in rabbits were made. The effect of astragalus and zinc sulfate on superoxid dismutase(SOD)?oxidase(XO)?malodialdeyde(MDA) and pulmonary surfactant (PS) in-flowing and out-going pulmonary blood (IPB, OPB) and lung tissue were observed. Results: The administration of astragalus and zinc sulfate could decrease XO and MDA, and prevent the reduction of SOD and PS, and alleviate the lung tissue injury. Conclusion: The study suggested that astragalus and zinc sulfate might have preventive and therapeutic effects, through anti-lipid peroxidation on acute lung injury. |
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| Keywords: | astragalus membranaceus zinc sulfate reperfusion injury respiratory distress syndrom adult |
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