Sequential Evaluation of Plasma Retinol-Binding Protein Response to Vitamin A Administration in Very-Low-Birth-Weight Neonates |
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| Affiliation: | 1. Departments of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA, 23298-0034, USA;2. Departments of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, 23298, USA;3. Departments of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA;4. Department of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA, 23298, USA;1. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China;2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China;1. SCF Pharma, Ste-Luce, QC, Canada;2. Départment de Sciences infirmières, Université du Québec à Rimouski, Rimouski, QC, Canada;3. Départment de Biologie, Université du Québec à Rimouski, Rimouski, QC, Canada;1. Ophthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht, the Netherlands;2. Department of Ophthalmology, University Medical Center Utrecht, Utrecht, the Netherlands;3. Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands;4. Department Molecular Cancer Research, University Medical Center Utrecht, Utrecht, the Netherlands;5. Section of Metabolic Diseases, and the Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands;1. Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa;2. Department of Pediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands;3. Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands |
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| Abstract: | Vitamin A (retinol) deficiency is associated with impaired healing from lung injury in very-low-birth-weight (VLBW) neonates susceptible to bronchopulmonary dysplasia (BPD). Vitamin A supplementation from birth may ameliorate this adverse outcome. We hypothesized that plasma retinol-binding protein (REP) response to vitamin A administration, which provides a dynamic measure of vitamin A status, might be useful for early recognition of vitamin A deficiency in VLBW neonates at risk for BPD. We prospectively studied 20 VLBW neonates (inclusion criteria: birth weight <1300 g, gestational age <30 weeks, need for supplemental oxygen and mechanical ventilation for >24 h after birth) who were eligible to receive vitamin A supplementation. In addition to sequential assessment of vitamin A status, we measured plasma RBP just before and 3 and 6 h after an intramuscular injection of vitamin A (2000 IU/kg retinyl palmitate) on Postnatal Days 1, 7, 15, 21, 29, and 43. The percentage increase in plasma RBP (Δ-RBP) was calculated. A high plasma Δ-RBP value (>8%) is indicative of vitamin A deficiency. Based on pulmonary outcome, the infants were divided into two groups: BPD (n = 12) and No BPD (n = 8). Mean vitamin A intake ranged from 1414 to 2114 IU/kg/day and did not differ between infant groups. Mean plasma vitamin A concentration increased from baseline levels on Postnatal Day 1 to levels within the desired range of 1.05-2.10 μmol/liter (30.0-60.0 μg/dl) during supplementation period in both infant groups. Infants with BPD, in contrast to those without BPD, had worsening plasma Δ-RBP values from Postnatal Day 15, indicative of persistence of vitamin A deficiency despite supplementation and normalization of plasma vitamin A concentration. We conclude that plasma RBP response to vitamin A administration is useful for early recognition of vitamin A deficiency in VLBW neonates at risk for BPD. |
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