女性胆结石患者垂体—性腺轴激素变化的研究

本文采用放射免疫法测定了62例女性胆囊结石和15例女性肝胆管结石患者血清 FSH、LH和血浆 E_2、P、T 的含量.并与42例正常妇女对照分析。实验结果表明育龄女性胆囊结石患者 E_2含量明显升高(P<0.01),T 含量显著减少(P<0.05),绝经后胆囊结石患者 T 含量明显减少(P<0.01),P 含量显著升高(P<0.01),育龄女性和绝经后胆囊结石患者 E_2/T 比值与对照组相比均有显著性差异(P<0.01),育龄女性肝胆管结石患者卵泡期 E_2、T 及 E_2/T 比值有显著性差异。提示女性胆结石患者存在明显的垂体一性腺轴激素合成或代谢的异常。

The Study of Pituitary Gonad Axis Hormones Changes in Women Patient with Cholelithiasis

By radiommunoussary,we determined the concen- tration of serum foUiculartstimuatng hormone(FSH), luteinlzing hormone(LH).and that of plasma estradio (E_2),progesterone(P),testosterone(T)in 62 women patients with gallstones and in 45 women patients with hepatic bile duct stones and in 42 healthy women subj- ects as control.The results were as follow:comparing with that in healthy subjects,the level of plasma E_2 was greatly higher(P<0.01)and the level of plasma T was signffieantly lower(P<0. 05) in reproductive aged wom- en with gaLlstones. The postmenopausalt women with gallstones had lower plasma T values and much higher plasma P values than healthy subjects(P<0.01).Between the women patients with gallstones and healthy subjects,there were significant difference in the radio of E_2/T(p<0. 01). Obviously,there were significant changes in the values of plasma E_2,T and the radio E_2/T in women with hepa tic bile duct stones when they were at graafian follicle period.It is concluded that the synthesis or metablism of pituitary gonad axis hormones in women partients with cholelithiasis is significantly obnormal.