5-氨基酮戊酸光动力治疗基底细胞癌疗效评价

目的：评价5-氨基酮戊酸光动力(ALA-PDT) 治疗基底细胞癌的疗效及安全性。方法：回顾2016-2019年我院进行ALA-PDT治疗的17例基底细胞癌患者（浅表型14例，结节型3例）的临床资料。结果：14例浅表型基底细胞癌患者中13例患者皮损消退，仅留轻微色素沉着或色素减退，2例复发,1例于治疗后6个月后复发，1例于治疗后10个月后复发。3例结节型患者皮损面积缩小>50％。所有患者均未发生严重不良反应。结论：光动力治疗浅表型基底细胞癌临床效果好，复发率低，较为安全，对于结节型基底细胞癌治疗效果较差。

Assessment the efficacy of 5-aminolevulinic acid mediated photodynamic therapy for the treatment of basal cell carcinoma

Objective: To assess the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of basal cell carcinoma. Methods: The data of 17 patients with basal cell carcinoma（BCC）(including 14 cases of superficial BCC and 3 cases of nodular BCC) treated by ALA-PDT were analyzed retrospectively. Results: Of 14 patients with superficial BCC, the lesions in 13 cases were in complete remission with slight pigmentation or hypopigmentation left. Two of them recurred at month 6 and month 10 after treatment respectively. The size of the lesions in 3 patients with nodular BCC reduced by 50%. There was no obvious adverse reaction in all patients. Conclusion: ALA-PDT has good clinical effect and low recurrence rate for the treatment of superficial BCC. However, it has low efficacy for the treatment of nodular BCC.