苦芪方治疗糖尿病肾病及对血糖血脂影响的临床研究

目的：观察苦芪方治疗糖尿病肾病疗效及对血糖血脂的影响。方法：将60例患者随机分为2组。治疗组35例，以苦芪方（处方：黄芪、山药、益母草、苦瓜干、玄参、番石榴、牛蒡子、天花粉、甘草）治疗；对照组25俐，以科素亚治疗。2组疗程均为3月。结果：总有效率治疗组为80．0％，对照组为64．0％，2组比较，差异有显著性意义（P〈0．05）。治疗后治疗组备期24h尿蛋白定量、尿白蛋白排泄率（UAER）、餐后2小时血糖（P2BG）、血清胆固醇（TC）、高密度脂蛋白-胆固醇（HDL—C）、低密度脂蛋白-胆固醇（LDL—C）、血压等指标均有明显改善，与治疗前比较，差异均有显著性意义（P〈0．05）。治疗后对照组仅UAER及血压有所变化，与治疗前比较，差异均有显著性意义（P〈0．05）。结论：苦芪方治疗糖尿病肾病有较好的临床疗效，并具有减少24h尿蛋白定量、降低尿白蛋白排泄率及改善餐后血糖和脂质代谢等作用。

A Clinical Study of Kuqi Fang on the Treatment of Diabetic Nephrosis and Its Influence on blood Glucose and Blood Lipid

Objective: To observe the curative effect of Kuqi Fang (KF) for diabetic nephrosis (DN) and its influence on blood glucose and blood lipid. Methods: 60 cases were allocated to 2 groups randomly. The treatment group (35 cases) was treated by KF(composed of Radix Astragali, Rhizoma Dioscoreae, Herba Leonuri, Fructus Momordicae Charantiae (dried), Radix Scrophu-lariae, Fructus Psdsidii Guajavae, Fructus Arctii, Radix Tri-chosanthis and Radix Glycyrrhizae), the control group (25 cases) by cozaar. Three months constituted a course of treatment. Re-sults: The total effective rate was 80. 0% and 64. 0% in treatment group and control group respectively ( P < 0. 05). After treatment, the 24h quantitative urinary protein, urinary albumin excretion rate (UAER), blood glucose 2h after meal, serum cholesterol, HDL-C, LDL - C and blood pressure (BP) were markedly improved, the difference was significant as compared with before treatment (P < 0. 05). After Treatment, the UAER and BP in control group was changed and the difference was significant as compared with before treatment (P < 0.05). Conclusion: KF is effective for DN and can decrease 24h quantitative urinary protein, UAER and improve the blood glucose after meal and metabolism of lipid.