阿托伐他汀对老年非缺血性心力衰竭患者心功能的影响 |
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引用本文: | 张素华,罗艳利,赵维江,曹治宸,黄建敏,潘丽萍.阿托伐他汀对老年非缺血性心力衰竭患者心功能的影响[J].河北医药,2009,31(21). |
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作者姓名: | 张素华 罗艳利 赵维江 曹治宸 黄建敏 潘丽萍 |
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作者单位: | 河北医科大学第三医院老年病科,石家庄市,050051 |
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摘 要: | 目的观察阿托伐他汀对老年非缺血性心力衰竭患者血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)和Ⅰ型胶原羧基端交联肽(CITP)水平的影响,探讨他汀类药物减少或延缓老年非缺血性心力衰竭发生和发展的可能机制。方法选择经冠状动脉造影证实的老年非缺血性心力衰竭患者38例作为研究对象,随机分为他汀类治疗组(阿托伐他汀10mg/d)及常规治疗组,每组19例。随访6个月,测定治疗前后患者血清TNF-α、IL-6、MMP-9和CITP的水平,并通过超声心动图观察治疗前后左心室射血分数(LVEF)及左心室大小。结果治疗过程中有1例患者因转氨酶增高停用阿托伐他汀治疗。2组治疗后血清TNF-α、IL-6、MMP-9和CITP水平与治疗前相比均下降(P<0.05)。治疗后治疗组血清TNF-α、IL-6、MMP9和CITP水平及LVEF明显低于对照组(P<0.01)。结论阿托伐他汀可以降低非缺血性心力衰竭患者血清TNF-α、IL-6、MMP-9和CITP的水平,延缓老年非缺血性心力衰竭的发生发展。
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关 键 词: | 阿托伐他汀 非缺血性心力衰竭 肿瘤坏死因子-α 白细胞介素-6 基质金属蛋白酶-9 Ⅰ型胶原羧基端交联肽 |
Effect of atorvastain therapy on cardiac function in patients with non-ischemic heart failure |
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Affiliation: | ZHANG Suhua; Luo Yanli; ZHAO Weijiang; et al.The Third Hospital of Hebei Medical University; Shijiazhuang 050051; China; |
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Abstract: | Objective To observe the effect of atorvastain on serum levels of tumor necrosis factor a(TNF-α),interleukin 6(IL-6),matrix metalloproteases-9(MMP-9)and carboxy terminal telopeptide of collagen type Ⅰ(CITP)in patients with non-ischemic heart failure,and to investigate the possible mechanism of HMG-COA reductase inhibitor to improve cardiac function in patients with non-ischemic heart failure.Methods Thirty-eight patients with non-ischemic heart failure identified by angiography were divided into atorvastain... |
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Keywords: | atorvastain non-ischemic heart failure tumor necrosis factor-α interleukin-6 matrix metalloproteases-9 carboxy terminal telopeptide of collagen type Ⅰ |
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